1-(1-(2-trifluoromethoxy-4-(4-piperidinyloxy)phenylacetyl)-piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one

Base Information

Chemical Name:1-(1-(2-trifluoromethoxy-4-(4-piperidinyloxy)phenylacetyl)-piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one
CAS No.:221285-22-9
Molecular Formula:C₂₇H₃₀F₃N₃O₅
Molecular Weight:533.548
Hs Code.:

Synonyms:1-(1-(2-trifluoromethoxy-4-(4-piperidinyloxy)phenylacetyl)-piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one

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Chemical Property of 1-(1-(2-trifluoromethoxy-4-(4-piperidinyloxy)phenylacetyl)-piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one

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Technology Process of 1-(1-(2-trifluoromethoxy-4-(4-piperidinyloxy)phenylacetyl)-piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one

There total 10 articles about 1-(1-(2-trifluoromethoxy-4-(4-piperidinyloxy)phenylacetyl)-piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 221286-44-8
4-(4-{2-oxo-2-[4-(2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidin-1-yl]-ethyl}-3-trifluoromethoxy-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

: 221285-22-9
1-(1-(2-trifluoromethoxy-4-(4-piperidinyloxy)phenylacetyl)-piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one

Guidance literature:: With hydrogenchloride; In ethyl acetate;
DOI:10.1016/S0960-894X(99)00181-X

Reference yield:

: 220996-81-6
(4-bromo-2-(trifluoromethoxy)phenyl)methanol

: 221285-22-9
1-(1-(2-trifluoromethoxy-4-(4-piperidinyloxy)phenylacetyl)-piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / 4-(dimethylamino)pyridine / CH₂Cl₂

2: 1.) n-BuLi, 2.) B(OMe)3, 3.) H₂O₂, HOAc

3: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran

4: 95 percent / Bu₄NF / tetrahydrofuran

5: 85 percent / CBr₄, Ph₃P / diethyl ether

6: 90 percent / dimethylformamide

7: 75 percent / conc. HCl, HOAc

8: EDC, HOBT, i-Pr₂NEt / dimethylformamide

9: 95 percent / HCl (gas) / ethyl acetate

With hydrogenchloride; dmap; n-butyllithium; Trimethyl borate; carbon tetrabromide; tetrabutyl ammonium fluoride; dihydrogen peroxide; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00181-X

Reference yield:

: 4-bromo-1-iodo-2-(trifluormethoxy)benzene

: 221285-22-9
1-(1-(2-trifluoromethoxy-4-(4-piperidinyloxy)phenylacetyl)-piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one

Guidance literature:: Multi-step reaction with 11 steps

1: 85 percent / n-BuLi / tetrahydrofuran

2: 95 percent / NaBH₄ / methanol

3: 95 percent / 4-(dimethylamino)pyridine / CH₂Cl₂

4: 1.) n-BuLi, 2.) B(OMe)3, 3.) H₂O₂, HOAc

5: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran

6: 95 percent / Bu₄NF / tetrahydrofuran

7: 85 percent / CBr₄, Ph₃P / diethyl ether

8: 90 percent / dimethylformamide

9: 75 percent / conc. HCl, HOAc

10: EDC, HOBT, i-Pr₂NEt / dimethylformamide

11: 95 percent / HCl (gas) / ethyl acetate

With hydrogenchloride; dmap; sodium tetrahydroborate; n-butyllithium; Trimethyl borate; carbon tetrabromide; tetrabutyl ammonium fluoride; dihydrogen peroxide; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00181-X