4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene

Base Information

Chemical Name:4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene
CAS No.:220996-83-8
Molecular Formula:C₁₄H₂₁F₃O₃Si
Molecular Weight:322.4
Hs Code.:

Synonyms:4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene

Suppliers and Price of 4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene

Chemical Property:

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Technology Process of 4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene

There total 4 articles about 4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121-43-7,63156-11-6
Trimethyl borate

: 220996-82-7
4-bromo-1-(tert-butyldimethylsilyloxymethyl)-2-trifluoromethoxy-benzene

: 220996-83-8
4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene

Guidance literature:: With n-butyllithium; dihydrogen peroxide; acetic acid; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 220996-81-6
(4-bromo-2-(trifluoromethoxy)phenyl)methanol

: 220996-83-8
4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 4-(dimethylamino)pyridine / CH₂Cl₂

2: 1.) n-BuLi, 2.) B(OMe)3, 3.) H₂O₂, HOAc

With dmap; n-butyllithium; Trimethyl borate; dihydrogen peroxide; acetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00181-X

Reference yield:

: 4-bromo-1-iodo-2-(trifluormethoxy)benzene

: 220996-83-8
4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / n-BuLi / tetrahydrofuran

2: 95 percent / NaBH₄ / methanol

3: 95 percent / 4-(dimethylamino)pyridine / CH₂Cl₂

4: 1.) n-BuLi, 2.) B(OMe)3, 3.) H₂O₂, HOAc

With dmap; sodium tetrahydroborate; n-butyllithium; Trimethyl borate; dihydrogen peroxide; acetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0960-894X(99)00181-X