(4-Bromo-2-(trifluoromethoxy)phenyl)methanol

Base Information

• Chemical Name: (4-Bromo-2-(trifluoromethoxy)phenyl)methanol
• CAS No.: 220996-81-6
• Molecular Formula: C8H6BrF3O2
• Molecular Weight: 271.034
• Hs Code.: 2909499000
• Mol file: 220996-81-6.mol

Synonyms:4-Bromo-2-(Trifluoromethoxy)Benzyl alcohol;(4-Bromo-2-(trifluoromethoxy)phenyl)methanol;

Chemical Property of (4-Bromo-2-(trifluoromethoxy)phenyl)methanol

Chemical Property:

• Vapor Pressure: 0.0131mmHg at 25°C
• Boiling Point: 248oC at 760 mmHg
• Flash Point: 103.8oC
• PSA: 29.46000
• Density: 1.695g/cm3
• LogP: 2.84000
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(4-Bromo-2-(trifluoromethoxy)phenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Bromo-2-(trifluoromethoxy)phenyl)methanol

There total 2 articles about (4-Bromo-2-(trifluoromethoxy)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-bromo-2-[(trifluoromethyl)oxy]benzaldehyde (220996-80-5) → (4-bromo-2-(trifluoromethoxy)phenyl)methanol (220996-81-6)

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1016/S0960-894X(99)00181-X

Reference yield:

4-bromo-1-iodo-2-(trifluormethoxy)benzene → (4-bromo-2-(trifluoromethoxy)phenyl)methanol (220996-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / n-BuLi / tetrahydrofuran

2: 95 percent / NaBH₄ / methanol

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; methanol;

DOI:10.1016/S0960-894X(99)00181-X

Reference yield: 95.0%

tert-butyldimethylsilyl chloride (18162-48-6) + (4-bromo-2-(trifluoromethoxy)phenyl)methanol (220996-81-6) → 4-bromo-1-(tert-butyldimethylsilyloxymethyl)-2-trifluoromethoxy-benzene (220996-82-7)

Guidance literature:

With dmap; In dichloromethane;

DOI:10.1016/S0960-894X(99)00181-X

upstream raw materials:

4-bromo-2-[(trifluoromethyl)oxy]benzaldehyde

Downstream raw materials:

4-bromo-1-(tert-butyldimethylsilyloxymethyl)-2-trifluoromethoxy-benzene

4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene

4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl bromide

4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl alcohol

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