3-ethyl-3-phenylisobenzofuran-1(3H)-one

Base Information

• Chemical Name: 3-ethyl-3-phenylisobenzofuran-1(3H)-one
• CAS No.: 107796-81-6
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.286
• Mol file: 107796-81-6.mol

Synonyms:3-ethyl-3-phenylisobenzofuran-1(3H)-one

Chemical Property of 3-ethyl-3-phenylisobenzofuran-1(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-ethyl-3-phenylisobenzofuran-1(3H)-one

There total 5 articles about 3-ethyl-3-phenylisobenzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C16H16O2 → 3-ethyl-3-phenylisobenzofuran-1(3H)-one (107796-81-6)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; In methanol; acetonitrile; at 20 ℃; regioselective reaction; Electrochemical reaction;

DOI:10.1021/acs.orglett.7b03617

Reference yield: 77.0%

ethyl 2-iodobenzoate (1829-28-3) + 1-phenyl-propan-1-one (93-55-0) → 3-ethyl-3-phenylisobenzofuran-1(3H)-one (107796-81-6)

Guidance literature:

ethyl 2-iodobenzoate; With C₂₄H₃₂O₂^(2-)*C₄H₉Mg⁽¹⁺⁾*Li⁽¹⁺⁾; In tetrahydrofuran; for 1h; Schlenk technique; Inert atmosphere;

1-phenyl-propan-1-one; In tetrahydrofuran; at -60 - 20 ℃; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.202100899

Reference yield: 60.0%

2-(1-phenylethenyl)benzoic acid (17582-84-2) + potassium trifluoro(methyl)boranuide → 3-ethyl-3-phenylisobenzofuran-1(3H)-one (107796-81-6)

Guidance literature:

With manganese(IV) oxide; 1,10-Phenanthroline; copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 105 ℃; for 24h; Molecular sieve; Sealed tube; Inert atmosphere;

DOI:10.1039/c9sc02835h

upstream raw materials:

ethylmagnesium iodide

2-Benzoylbenzoic acid

2-Benzylbenzoic acid

2-(1-phenylethenyl)benzoic acid

Downstream raw materials:

2-(1-phenyl-propenyl)-benzoic acid

2-((E)-2-chloro-1-phenyl-propenyl)-benzoic acid amide

2-((Z)-2-chloro-1-phenyl-propenyl)-benzoic acid

2-((E)-2-chloro-1-phenyl-propenyl)-benzoic acid