tert-butyl-1-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)-10,10-dimethyl-1,8-dioxo-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate

Base Information

Chemical Name:tert-butyl-1-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)-10,10-dimethyl-1,8-dioxo-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate
CAS No.:1610839-77-4
Molecular Formula:C₂₇H₄₂N₄O₈
Molecular Weight:550.652
Hs Code.:

Synonyms:tert-butyl-1-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)-10,10-dimethyl-1,8-dioxo-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate

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Chemical Property of tert-butyl-1-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)-10,10-dimethyl-1,8-dioxo-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate

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Technology Process of tert-butyl-1-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)-10,10-dimethyl-1,8-dioxo-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate

There total 4 articles about tert-butyl-1-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)-10,10-dimethyl-1,8-dioxo-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: (2R,4R)-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxane-4-carboxylic acid

: 203258-44-0
N,N'-bis-(tert-butoxycarbonyl)-N''-(2-aminoethyl)-guanidine

: 1610839-77-4
tert-butyl-1-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)-10,10-dimethyl-1,8-dioxo-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.030

Reference yield:

: (2R,4R)-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxane-4-carbaldehyde

: 1610839-77-4
tert-butyl-1-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)-10,10-dimethyl-1,8-dioxo-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium dihydrogenphosphate; sodium chlorite / dichloromethane; water; acetone / 0.25 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1016/j.bmc.2014.04.030

Reference yield:

: [(2R,4R)-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]methanol

: 1610839-77-4
tert-butyl-1-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)-10,10-dimethyl-1,8-dioxo-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: sodium dihydrogenphosphate; sodium chlorite / dichloromethane; water; acetone / 0.25 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1016/j.bmc.2014.04.030