dimethyl 4-(N-methyltosylamido)-3-hexylcyclohexa-1,4-diene-1,2-dicarboxylate

Base Information

Chemical Name:dimethyl 4-(N-methyltosylamido)-3-hexylcyclohexa-1,4-diene-1,2-dicarboxylate
CAS No.:1486515-66-5
Molecular Formula:C₂₄H₃₃NO₆S
Molecular Weight:463.595
Hs Code.:

Synonyms:dimethyl 4-(N-methyltosylamido)-3-hexylcyclohexa-1,4-diene-1,2-dicarboxylate

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Chemical Property of dimethyl 4-(N-methyltosylamido)-3-hexylcyclohexa-1,4-diene-1,2-dicarboxylate

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Technology Process of dimethyl 4-(N-methyltosylamido)-3-hexylcyclohexa-1,4-diene-1,2-dicarboxylate

There total 7 articles about dimethyl 4-(N-methyltosylamido)-3-hexylcyclohexa-1,4-diene-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1486515-64-3
(Z)-N-(1-phenyloct-1-en-1-yl)-N-methyltosylamide

: 762-42-5
dimethyl acetylenedicarboxylate

: 1486515-66-5
dimethyl 4-(N-methyltosylamido)-3-hexylcyclohexa-1,4-diene-1,2-dicarboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; In toluene; at 110 ℃; for 70h; Schlenk technique;
DOI:10.1021/ol4031028

Reference yield:

: 1486515-50-7
(E)-N-methyl-N-(1-tributylstannyl-oct-1-en-1-yl)tosylamide

: 1486515-66-5
dimethyl 4-(N-methyltosylamido)-3-hexylcyclohexa-1,4-diene-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: iodine / dichloromethane / 3 h / 0 °C

2: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 20 °C / Schlenk technique; Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride / toluene / 70 h / 110 °C / Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; iodine; In dichloromethane; N,N-dimethyl-formamide; toluene; 2: |Stille Cross Coupling / 3: |Diels-Alder Cycloaddition;
DOI:10.1021/ol4031028

Reference yield:

: 1007597-75-2
N,4-dimethyl-N-(oct-1-yn-1-yl)benzenesulfonamide

: 1486515-66-5
dimethyl 4-(N-methyltosylamido)-3-hexylcyclohexa-1,4-diene-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydroquinone; tris(t-butyl isocyanide)tricarbonylmolybdenum(O); carbon monoxide / tetrahydrofuran / 55 °C / Schlenk technique

2: iodine / dichloromethane / 3 h / 0 °C

3: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 20 °C / Schlenk technique; Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride / toluene / 70 h / 110 °C / Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; tris(t-butyl isocyanide)tricarbonylmolybdenum(O); carbon monoxide; iodine; hydroquinone; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 3: |Stille Cross Coupling / 4: |Diels-Alder Cycloaddition;
DOI:10.1021/ol4031028