Ethyl estrone-3-oxylacetate

Base Information

• Chemical Name: Ethyl estrone-3-oxylacetate
• CAS No.: 41164-32-3
• Molecular Formula: C₂₂H₂₈O₄
• Molecular Weight: 356.462
• Mol file: 41164-32-3.mol

Synonyms:3-ethyloxycarbonylmethylenoxyestrone

Chemical Property of Ethyl estrone-3-oxylacetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl estrone-3-oxylacetate

There total 3 articles about Ethyl estrone-3-oxylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Estrone (53-16-7) + ethyl bromoacetate (105-36-2) → 3-ethyloxycarbonylmethylenoxyestrone (41164-32-3)

Guidance literature:

Estrone; With sodium ethanolate; In tetrahydrofuran; ethanol; at 20 ℃; for 0.5h; Inert atmosphere;

ethyl bromoacetate; In tetrahydrofuran; ethanol; at 55 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmc.2009.03.057

Reference yield:

→ 3-O-Carbaethoxymethyloestron (41164-32-3)

Guidance literature:

Oestron (5), Aethyl bromacetat;

Reference yield:

→ 3-Ethoxycarbonylmethoxy-17-oxo-oestratrien-(1,3,5(10)) (41164-32-3)

Guidance literature:

Aus 3-Carboxymethoxy-17-oxo-oestratrien-(1,3,5(10)) in ethanol. HCl;

upstream raw materials:

Estrone

ethyl bromoacetate

Downstream raw materials:

C₄₉H₅₄Cl₂N₆O₉

C₅₅H₆₆Cl₂N₆O₉

C₅₅H₆₆Cl₂N₆O₉

C₅₆H₆₇Cl₂N₅O₁₀

Refernces

• 1、 Leung, Joe C. T.,Sammis, Glenn M.. "Radical decarboxylative fluorination of aryloxyacetic acids using N-fluorobenzenesulfonimide and a photosensitizer". supporting information. p. 2197 - 2204. Retrieved 2015/04/14.
• 2、 Sansiaume, Elodie,Ricoux, Remy,Gori, Didier,Mahy, Jean-Pierre. "Oxidation of organic molecules in homogeneous aqueous solution catalyzed by hybrid biocatalysts (based on the Trojan Horse strategy)". scheme or table. p. 1593 - 1600. Retrieved 2010/11/02.