4,4,5,5-tetramethyl-2-[(2S)-2-[4-(trifluoromethyl)phenyl]propyl]-1,3,2-dioxaborolane

Base Information

• Chemical Name: 4,4,5,5-tetramethyl-2-[(2S)-2-[4-(trifluoromethyl)phenyl]propyl]-1,3,2-dioxaborolane
• CAS No.: 1262985-43-2
• Molecular Formula: C₁₆H₂₂BF₃O₂
• Molecular Weight: 314.156

Synonyms:4,4,5,5-tetramethyl-2-[(2S)-2-[4-(trifluoromethyl)phenyl]propyl]-1,3,2-dioxaborolane

Chemical Property of 4,4,5,5-tetramethyl-2-[(2S)-2-[4-(trifluoromethyl)phenyl]propyl]-1,3,2-dioxaborolane

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Technology Process of 4,4,5,5-tetramethyl-2-[(2S)-2-[4-(trifluoromethyl)phenyl]propyl]-1,3,2-dioxaborolane

There total 5 articles about 4,4,5,5-tetramethyl-2-[(2S)-2-[4-(trifluoromethyl)phenyl]propyl]-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-trifluoromethyl-α-methylstyrene (55186-75-9) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 4,4,5,5-tetramethyl-2-[(2S)-2-[4-(trifluoromethyl)phenyl]propyl]-1,3,2-dioxaborolane (1262985-43-2)

Guidance literature:

With C₂₆H₃₆CoN₃O; In tetrahydrofuran; at 25 ℃; for 3h; enantioselective reaction; Inert atmosphere; Glovebox;

DOI:10.1021/ja5093908

Reference yield: 90.0%

→ 4,4,5,5-tetramethyl-2-[(2S)-2-[4-(trifluoromethyl)phenyl]propyl]-1,3,2-dioxaborolane (1262985-43-2)

Guidance literature:

With C₂₆H₃₆CoN₃O; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield: 79.0%

4-trifluoromethyl-α-methylstyrene (55186-75-9) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5-tetramethyl-2-[(2S)-2-[4-(trifluoromethyl)phenyl]propyl]-1,3,2-dioxaborolane (1262985-43-2) + (R)-4,4,5,5-tetramethyl-2-(2-(4-(trifluoromethyl)phenyl)propyl)-1,3,2-dioxaborolane

Guidance literature:

With CuCl; C₃H₂N₂Ph₂(C₁₀H₆Ph)(C₆H₄SO₃); In tetrahydrofuran; methanol; -50°C; 48 h;

DOI:10.1002/anie.201102398

upstream raw materials:

4-trifluoromethyl-α-methylstyrene

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

bis(pinacol)diborane

1-trifluoromethyl-4-vinyl-benzene

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