4-(2-Benzylidenehydrazinyl)benzene-1-sulfonamide

Base Information

• Chemical Name: 4-(2-Benzylidenehydrazinyl)benzene-1-sulfonamide
• CAS No.: 21305-93-1
• Molecular Formula: C13H13 N3 O2 S
• Molecular Weight: 275.331
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID80385201
• Mol file: 21305-93-1.mol

Synonyms:21305-93-1;4-(2-benzylidenehydrazinyl)benzenesulfonamide;4-(2-Benzylidenehydrazinyl)benzene-1-sulfonamide;HMS2600J17;CBDivE_001145;DTXSID80385201

Chemical Property of 4-(2-Benzylidenehydrazinyl)benzene-1-sulfonamide

Chemical Property:

• PSA: 92.93000
• LogP: 3.63410
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 275.07284784
• Heavy Atom Count: 19
• Complexity: 389

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=NNC2=CC=C(C=C2)S(=O)(=O)N

Technology Process of 4-(2-Benzylidenehydrazinyl)benzene-1-sulfonamide

There total 4 articles about 4-(2-Benzylidenehydrazinyl)benzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzaldehyde (100-52-7) + 4-aminosulfonylphenylhydrazine (4392-54-5) → 1-benzylidene-2-(4-(aminosulfonyl)phenyl)hydrazine (21305-93-1)

Guidance literature:

With acetic acid; In methanol; for 4h; Dean-Stark; Heating;

DOI:10.1016/j.ejmech.2012.08.046

Reference yield:

4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0) + benzaldehyde (100-52-7) → 1-benzylidene-2-(4-(aminosulfonyl)phenyl)hydrazine (21305-93-1)

Guidance literature:

With sodium acetate; In ethanol; Reflux;

DOI:10.1016/j.bioorg.2015.11.001

Reference yield:

sulfanilamide (63-74-1) → 4-benzylidenehydrazino-benzenesulfonic acid amide (21305-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tin (II)-chloride; aqueous hydrochloric acid / Diazotization

With hydrogenchloride; tin(ll) chloride;

upstream raw materials:

benzaldehyde

4-aminosulfonylphenylhydrazine

sulfanilamide

4-hydrazinobenzene-1-sulfonamide hydrochloride

Downstream raw materials:

4-(3,N'''-diphenyl-formazano)-benzenesulfonic acid amide

C₁₅H₁₅N₃O₃S₂