isoquassin

Base Information

Chemical Name:isoquassin
CAS No.:21293-20-9
Molecular Formula:C22H28 O6
Molecular Weight:388.45
Hs Code.:

Synonyms:Isoquassin(7CI); Phenanthro[10,1-bc]pyran-1,5,11(4H)-trione,3a,6a,7,7a,8,11a,11b,11c-octahydro-2,10-dimethoxy-3,8,11a,11c-tetramethyl-(8CI); Phenanthro[10,1-bc]pyran, picrasa-2,12-diene-1,11,16-trione deriv.;Picrasmin

Suppliers and Price of isoquassin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of isoquassin

Chemical Property:

Melting Point:222-225°
Boiling Point:586.3±50.0 °C(Predicted)
PSA：78.90000
Density:1.23±0.1 g/cm3(Predicted)
LogP:2.81900

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of isoquassin

There total 72 articles about isoquassin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 76-78-8,21293-20-9,75991-65-0,96646-68-3,135556-51-3,139402-22-5,139402-23-6
4-epiquassin

: 76-78-8,21293-20-9,75991-65-0,96646-68-3,135556-51-3,139402-22-5,139402-23-6
d,l-quassin

Guidance literature:: With 2,6-dichloro-benzonitrile; In benzene; for 3.3h;

Reference yield:

: 75924-48-0
neoquassin β-O-methyl ether

: 76-78-8,21293-20-9,75991-65-0,96646-68-3,135556-51-3,139402-22-5,139402-23-6
d,l-quassin

Guidance literature:: With acetic acid; Yield given. Multistep reaction; 1.) reflux, 25 min; 2.) reflux, 2 h;
DOI:10.1021/ja00324a023

Reference yield:

: 76200-28-7
(1β,9β)-1-hydroxypicras-12-en-16-one

: 76-78-8,21293-20-9,75991-65-0,96646-68-3,135556-51-3,139402-22-5,139402-23-6
d,l-quassin

Guidance literature:: Multi-step reaction with 7 steps

1: i-Bu₂AlH / toluene / 0.5 h / -78 °C

2: 92 percent / HCl / 30 h / 0 °C

3: 1.) B₂H₆; 2.) H₂O₂, aq. NaOH / 1.) THF, 0 deg C, 30 min then room temp., 2 h; 2.) 50 deg C, 45 min

4: 78 percent / CrO₃/pyridine / CH₂Cl₂ / 30 h / 0 °C

5: 35 percent / LDA, MoO_5.py.HMPA / tetrahydrofuran / 15 h / 0 °C

6: 57 percent / NaOMe / dimethylsulfoxide; methanol / 15 h / 10 °C

7: 1.) AcOH; 2.) Fetizon's reagent / 1.) reflux, 25 min; 2.) reflux, 2 h

With pyridine; chromium(VI) oxide; hydrogenchloride; sodium hydroxide; oxodiperoxymolybdenumpyridine hexamethylphosphoric triamide complex; dihydrogen peroxide; sodium methylate; diisobutylaluminium hydride; acetic acid; diborane; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/ja00324a023