(E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-en-1-ol

Base Information

• Chemical Name: (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-en-1-ol
• CAS No.: 497056-67-4
• Molecular Formula: C₄₂H₇₈O₇S₂Si₂
• Molecular Weight: 815.38

Synonyms:(E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-en-1-ol

Chemical Property of (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-en-1-ol

There total 5 articles about (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-enyl ester (777096-55-6) → (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-en-1-ol (497056-67-4)

Guidance literature:

With potassium carbonate; In methanol;

DOI:10.1021/ja0289649

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-en-1-ol (497056-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: TBAI; DIEA / CH₂Cl₂

2: K₂CO₃ / methanol

With tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

DOI:10.1021/ja0289649

Reference yield:

(E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-undec-8-ene-1,2-diol (777096-29-4) → (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-en-1-ol (497056-67-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,4,6-collidine / -78 °C

2: TBAI; DIEA / CH₂Cl₂

3: K₂CO₃ / methanol

With 2,4,6-trimethyl-pyridine; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

DOI:10.1021/ja0289649

upstream raw materials:

Acetic acid (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-enyl ester

(2-trimethylethylsilylethoxy)methyl chloride

(E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-undec-8-ene-1,2-diol

{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

Downstream raw materials:

10-hydroxy-11-(1-hydroxy-2,4-dimethyl-hepta-2,5-dienyl)-16-methoxy-18-(4-methoxy-benzyloxy)-9,17,19,21,23-pentamethyl-20-triisopropylsilanyloxy-15-(2-trimethylsilanyl-ethoxymethoxy)-13-oxa-1,5-dithia-spiro[5.17]tricos-21-en-14-one

10-[2-(4,6-dihydroxy-5-hydroxymethyl-3,7,9-trimethyl-dodeca-7,10-dienyl)-[1,3]dithian-2-yl]-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-2-(2-trimethylsilanyl-ethoxymethoxy)-undec-8-enoic acid

11-(2,4-dimethyl-1-triethylsilanyloxy-hepta-2,5-dienyl)-10-hydroxy-16-methoxy-18-(4-methoxy-benzyloxy)-9,17,19,21,23-pentamethyl-20-triisopropylsilanyloxy-15-(2-trimethylsilanyl-ethoxymethoxy)-13-oxa-1,5-dithia-spiro[5.17]tricos-21-en-14-one

C₆₈H₁₂₄O₁₀S₂Si₃

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