(2R)-1-(4-bromo-2-fluorophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

Base Information

Chemical Name:(2R)-1-(4-bromo-2-fluorophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine
CAS No.:1186083-88-4
Molecular Formula:C₁₈H₁₆BrF₅N₂O₂S
Molecular Weight:499.299
Hs Code.:

Synonyms:(2R)-1-(4-bromo-2-fluorophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

Suppliers and Price of (2R)-1-(4-bromo-2-fluorophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-1-(4-bromo-2-fluorophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

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Technology Process of (2R)-1-(4-bromo-2-fluorophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

There total 1 articles about (2R)-1-(4-bromo-2-fluorophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 216159-03-4
4-bromo-2-fluorobenzenesulfonyl chloride

(3R)-1-(4-fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine: 946399-84-4,1414960-67-0
(3R)-1-(4-fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine

: 1186083-88-4
(2R)-1-(4-bromo-2-fluorophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm900639u

Reference yield: 52.0%

: 110-91-8,99108-56-2
morpholine

: 1186083-88-4
(2R)-1-(4-bromo-2-fluorophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

: 865-48-5
sodium t-butanolate

: 946398-99-8
C₂₂H₂₅F₅N₂O₃S

: 946399-08-2
(2R)-4-(3-fluoro-4-(4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)morpholine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; Inert atmosphere;
DOI:10.1021/jm900639u