benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleric acid t-butyl ester

Base Information

Chemical Name:benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleric acid t-butyl ester
CAS No.:174743-59-0
Molecular Formula:C₂₆H₃₃NO₆
Molecular Weight:455.551
Hs Code.:

Synonyms:benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleric acid t-butyl ester

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Chemical Property of benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleric acid t-butyl ester

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Technology Process of benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleric acid t-butyl ester

There total 1 articles about benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleric acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 2448-45-5
Cbz-D-Phe

: 3519-30-0
L-α-hydroxyisovaleric acid t-butyl ester

: 174743-59-0
benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleric acid t-butyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 20h;
DOI:10.1016/0040-4020(95)00963-9

Reference yield: 100.0%

: 174743-59-0
benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleric acid t-butyl ester

: 174743-60-3
benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleric acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1016/0040-4020(95)00963-9

Reference yield:

: 174743-59-0
benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleric acid t-butyl ester

: 174743-65-8
benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleryl L-phenylalanyl D-lactyl D-phenylalanyl L-α-hydroisovaleryl L-phenylalanyl D-lactic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

2: 86 percent / dimethylaminopyridine, DCC / CH₂Cl₂ / 84 h / 0 °C

3: 99 percent / H₂, AcOH / 10percent Pd/C / ethyl acetate / 9 h / Ambient temperature

4: 55 percent / dimethylaminopyridine, DCC / CH₂Cl₂ / 72 h / 0 °C

5: 97 percent / TFA / CH₂Cl₂ / 7.5 h / Ambient temperature

With dmap; hydrogen; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/0040-4020(95)00963-9