(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Base Information

Chemical Name:(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAS No.:1402086-40-1
Molecular Formula:C₂₃H₂₅ClFN₅O₃
Molecular Weight:473.935
Hs Code.:

Synonyms:(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

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Chemical Property of (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Chemical Property:

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Technology Process of (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

There total 6 articles about (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-4-bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)but-2-enamide

: 506-59-2
N,N-dimethylammonium chloride

: 1402086-40-1
(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 0 - 40 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2015.08.026

Reference yield:

: 162012-67-1
N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

: 1402086-40-1
(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

1.2: 0 - 20 °C

2.1: iron; ammonium chloride / ethanol; water / 6 h / 60 °C

3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0 - 40 °C / Inert atmosphere

With iron; sodium hydride; potassium carbonate; ammonium chloride; triethylamine; potassium iodide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2015.08.026

Reference yield:

N⁴-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine: 402855-01-0
N⁴-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine

: 1402086-40-1
(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 °C

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0 - 40 °C / Inert atmosphere

With potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2015.08.026