1-{4-[(6-amino-9H-purin-9-yl)methyl]benzyl}-4-(dimethylamino)pyridinium bromide

Base Information

• Chemical Name: 1-{4-[(6-amino-9H-purin-9-yl)methyl]benzyl}-4-(dimethylamino)pyridinium bromide
• CAS No.: 1365671-46-0
• Molecular Formula: Br*C₂₀H₂₂N₇
• Molecular Weight: 440.346

Synonyms:1-{4-[(6-amino-9H-purin-9-yl)methyl]benzyl}-4-(dimethylamino)pyridinium bromide

Chemical Property of 1-{4-[(6-amino-9H-purin-9-yl)methyl]benzyl}-4-(dimethylamino)pyridinium bromide

Chemical Property:

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Technology Process of 1-{4-[(6-amino-9H-purin-9-yl)methyl]benzyl}-4-(dimethylamino)pyridinium bromide

There total 2 articles about 1-{4-[(6-amino-9H-purin-9-yl)methyl]benzyl}-4-(dimethylamino)pyridinium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

1-[4-(bromomethyl)benzyl]-4-(dimethylamino)pyridinium bromide (857440-95-0) + 7H-purin-6-ylamine (73-24-5,71660-29-2,71660-30-5) → 1-{4-[(6-amino-3H-purin-3-yl)methyl]benzyl}-4-(dimethylamino)pyridinium bromide (1365671-70-0) + 1-{4-[(6-amino-9H-purin-9-yl)methyl]benzyl}-4-(dimethylamino)pyridinium bromide (1365671-46-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.ejmech.2012.01.050

Reference yield:

1,4-bis(bromomethyl)benzene (623-24-5) + dmap (1122-58-3) → 1-{4-[(6-amino-3H-purin-3-yl)methyl]benzyl}-4-(dimethylamino)pyridinium bromide (1365671-70-0) + 1-{4-[(6-amino-9H-purin-9-yl)methyl]benzyl}-4-(dimethylamino)pyridinium bromide (1365671-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: butanone / 3 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 130 °C / Microwave irradiation

With potassium carbonate; In N,N-dimethyl-formamide; butanone;

DOI:10.1016/j.ejmech.2012.01.050

upstream raw materials:

1,4-bis(bromomethyl)benzene

dmap

1-[4-(bromomethyl)benzyl]-4-(dimethylamino)pyridinium bromide

7H-purin-6-ylamine

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