5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

Base Information

• Chemical Name: 5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
• CAS No.: 209224-91-9
• Molecular Formula: C10H8F3N3
• Molecular Weight: 227.189
• Hs Code.: 2933199090
• DSSTox Substance ID: DTXSID20346770
• Wikidata: Q82120012
• Mol file: 209224-91-9.mol

Synonyms:209224-91-9;5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine;3-(3-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOL-5-AMINE;5-(3-TRIFLUOROMETHYL-PHENYL)-2H-PYRAZOL-3-YLAMINE;3-[3-(Trifluoromethyl)phenyl]-1H-pyrazol-5-ylamine;3-[3-(Trifluoromethyl)phenyl]-1H-pyrazol-5-amine;Maybridge3_004121;SCHEMBL1914851;DTXSID20346770;CHEBI:195153;HMS1442L07;CCG-44321;MFCD04110829;AKOS000166741;AB17527;AT30418;DA-0842;IDI1_015508;CS-0213422;FT-0648479;EN300-1944571;Pyrazole-5-amine, 3-(3-trifluoromethylphenyl)-;5-[3-(triluoromethyl)phenyl]-1H-pyrazol-3-amine;A815020;J-510558;SR-01000634164-1;3-[3-(Trifluoromethyl)phenyl]-1H-pyrazol-5-ylamine #

Chemical Property of 5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

Chemical Property:

• Vapor Pressure: 1.96E-07mmHg at 25°C
• Melting Point: 130-132°C
• Refractive Index: 1.562
• Boiling Point: 425.1°C at 760 mmHg
• Flash Point: 210.9°C
• PSA: 54.70000
• Density: 1.401g/cm³
• LogP: 3.25890
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 227.06703175
• Heavy Atom Count: 16
• Complexity: 244

Purity/Quality:

97% ^*data from raw suppliers

3-[3-(Trifluoromethyl)phenyl]-1h-pyrazol-5-ylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)C(F)(F)F)C2=CC(=NN2)N

Technology Process of 5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

There total 4 articles about 5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-(3-(trifluoromethyl)phenyl)isoxazole (387824-53-5) → 5-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine (209224-91-9)

Guidance literature:

5-(3-(trifluoromethyl)phenyl)isoxazole; With potassium hydroxide; In ethanol; water; at 50 ℃; for 0.5h; Sealed tube;

With hydrazine; In tetrahydrofuran; ethanol; water; acetic acid; at 60 ℃; for 2.5h;

DOI:10.1055/s-0035-1561861

Reference yield: 82.0%

3-trifluoromethylbenzoylacetonitrile (27328-86-5) → 3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (209224-91-9)

Guidance literature:

With hydrazine; In ethanol; for 2h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2009.03.013

Reference yield:

2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (2003-10-3) → 3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (209224-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; water / Reflux

2: hydrazine / ethanol / Microwave irradiation

With hydrazine; In ethanol; water;

DOI:10.1016/j.bioorg.2018.11.029

upstream raw materials:

5-(3-(trifluoromethyl)phenyl)isoxazole

3-trifluoromethylbenzoylacetonitrile

2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone

Downstream raw materials:

N-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-yl)-2-mercaptoacetamide

4-(trifluoromethyl)-3-(3-(trifluoromethyl)phenyl)-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one

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