2-Amino-3-(1H-pyrrol-3-yl)propanoic acid

Base Information

Chemical Name:2-Amino-3-(1H-pyrrol-3-yl)propanoic acid
CAS No.:209216-56-8
Molecular Formula:C₇H₁₀N₂O₂
Molecular Weight:154.169
Hs Code.:2933990090
European Community (EC) Number:825-973-6
DSSTox Substance ID:DTXSID40561867
Nikkaji Number:J1.213.378B
Mol file:209216-56-8.mol

Synonyms:2-Amino-3-(1H-pyrrol-3-yl)propanoic acid;209216-56-8;3-(1H-Pyrrol-3-yl)alanine;SCHEMBL5321264;DTXSID40561867;AKOS014320944;2-Amino-3-(1H-pyrrol-3-yl)propanoicacid;1H-Pyrrole-3-propanoic acid, alpha-amino-;1H-Pyrrole-3-propanoicacid,alpha-amino-(9CI);EN300-1716732

Suppliers and Price of 2-Amino-3-(1H-pyrrol-3-yl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-Amino-3-(1H-pyrrol-3-yl)propanoicacid 95+%
1g
$ 772.00

Chemenu
2-amino-3-(1H-pyrrol-3-yl)propanoicacid 95%
1g
$ 729.00

American Custom Chemicals Corporation
3-(3-PYRROLYL)-DL-ALANINE 95.00%
1G
$ 1575.00

American Custom Chemicals Corporation
3-(3-PYRROLYL)-DL-ALANINE 95.00%
5MG
$ 499.70

Alichem
2-Amino-3-(1H-pyrrol-3-yl)propanoicacid
1g
$ 621.72

Total 8 raw suppliers

Chemical Property of 2-Amino-3-(1H-pyrrol-3-yl)propanoic acid

Chemical Property:

PSA：79.11000
LogP:0.66940
Storage Temp.:2-8°C
XLogP3:-2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:154.074227566
Heavy Atom Count:11
Complexity:149

Purity/Quality:

98% Min ^*data from raw suppliers

2-Amino-3-(1H-pyrrol-3-yl)propanoicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CNC=C1CC(C(=O)O)N

Technology Process of 2-Amino-3-(1H-pyrrol-3-yl)propanoic acid

There total 5 articles about 2-Amino-3-(1H-pyrrol-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 209216-60-4
3-(2-Benzyloxycarbonylamino-2-carboxy-ethyl)-pyrrole-1-carboxylic acid tert-butyl ester

: 209216-56-8,1163688-37-6
2-amino-3-(1H-pyrrol-3-yl)propanoic acid

Guidance literature:: With pyridine; trimethylsilyl iodide; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1016/S0040-4039(98)00722-9

Reference yield:

: 7126-39-8
pyrrole-3-carboxaldehyde

: 209216-56-8,1163688-37-6
2-amino-3-(1H-pyrrol-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / diisopropylethyl amine, dimethylaminopyridine / CH₂Cl₂ / 0 deg C, 3 h then r.t., 1 h

2: 85 percent / tetramethylguanidine / CH₂Cl₂ / -41 deg C, 1 h, r.t., 21 h then reflux, 12 h

3: 69 percent / sodium borohydride, nickel(II) chloride hexahydrate / methanol / 16 h / Ambient temperature

4: 85 percent / aq. NaOH / methanol / 0.25 h / 0 °C

5: 77 percent / trimethylsilyl iodide, pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; trimethylsilyl iodide; 1,1,3,3-tetramethylguanidine; N-ethyl-N,N-diisopropylamine; nickel dichloride; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)00722-9

Reference yield:

: 209216-57-9
tert-butyl 3-formylpyrrole-1-carboxylate

: 209216-56-8,1163688-37-6
2-amino-3-(1H-pyrrol-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / tetramethylguanidine / CH₂Cl₂ / -41 deg C, 1 h, r.t., 21 h then reflux, 12 h

2: 69 percent / sodium borohydride, nickel(II) chloride hexahydrate / methanol / 16 h / Ambient temperature

3: 85 percent / aq. NaOH / methanol / 0.25 h / 0 °C

4: 77 percent / trimethylsilyl iodide, pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; sodium hydroxide; sodium tetrahydroborate; trimethylsilyl iodide; 1,1,3,3-tetramethylguanidine; nickel dichloride; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)00722-9