4-amino-2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridine-5-carboxylic acid

Base Information

Chemical Name:4-amino-2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridine-5-carboxylic acid
CAS No.:1312594-19-6
Molecular Formula:C₁₆H₁₃BrN₂O₃S
Molecular Weight:393.261
Hs Code.:

Synonyms:4-amino-2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridine-5-carboxylic acid

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Chemical Property of 4-amino-2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridine-5-carboxylic acid

Chemical Property:

Boiling Point:585.6±50.0 °C(Predicted)
Density:1.619±0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of 4-amino-2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridine-5-carboxylic acid

There total 5 articles about 4-amino-2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312594-18-5
ethyl 4-amino-2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridine-5-carboxylate

: 1312594-19-6
4-amino-2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridine-5-carboxylic acid

Guidance literature:: ethyl 4-amino-2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridine-5-carboxylate; With water; sodium hydroxide; In dimethyl sulfoxide; at 150 ℃; for 1h;

With formic acid; In dimethyl sulfoxide; at 20 ℃; pH=6;

Reference yield:

: 586-37-8
1-(3-Methoxyphenyl)ethanone

: 1312594-19-6
4-amino-2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; acetic acid / 16 h / 70 °C / Inert atmosphere

2.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 0.75 h / 35 °C / Inert atmosphere

3.1: tin(IV) chloride / toluene / 3.5 h / 20 °C / Reflux

3.2: 20 °C

4.1: N-Bromosuccinimide / dichloromethane / 0.75 h / 20 °C

5.1: sodium hydroxide; water / dimethyl sulfoxide / 1 h / 150 °C

5.2: 20 °C / pH 6

With N-Bromosuccinimide; water; tin(IV) chloride; sodium hydrogencarbonate; sulfur; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 86604-43-5
2-(1-(3-methoxyphenyl)ethylidene)malononitrile

: 1312594-19-6
4-amino-2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 0.75 h / 35 °C / Inert atmosphere

2.1: tin(IV) chloride / toluene / 3.5 h / 20 °C / Reflux

2.2: 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 0.75 h / 20 °C

4.1: sodium hydroxide; water / dimethyl sulfoxide / 1 h / 150 °C

4.2: 20 °C / pH 6

With N-Bromosuccinimide; water; tin(IV) chloride; sodium hydrogencarbonate; sulfur; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;