Technology Process of (S)-1-[1,3]Dithian-2-yl-2-methyl-3-((S)-2-phenyl-[1,3]dioxan-4-yl)-propan-2-ol
There total 7 articles about (S)-1-[1,3]Dithian-2-yl-2-methyl-3-((S)-2-phenyl-[1,3]dioxan-4-yl)-propan-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: DIBALH / toluene / 0.5 h / -78 °C
2: NaBH4 / methanol / 0.5 h / 0 °C
3: 96 percent / Et3N / CH2Cl2 / 2 h / Ambient temperature
4: 1.) n-BuLi / 1.) HMPA, THF, -20 deg C, 2 h; 2.) HMPA, THF, -20 deg C, 2 h
5: IBX / dimethylsulfoxide; tetrahydrofuran / 5 h / Ambient temperature
6: tetrahydrofuran; diethyl ether / 1 h / Ambient temperature
7: 64 percent / BCl3, 1,3-propanedithiol / CH2Cl2 / 1 h / Ambient temperature
8: 63 percent / PPTS / CH2Cl2 / 48 h / Ambient temperature
With
1.3-propanedithiol; sodium tetrahydroborate; n-butyllithium; pyridinium p-toluenesulfonate; boron trichloride; diisobutylaluminium hydride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1016/S0040-4039(98)00619-4
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 96 percent / Et3N / CH2Cl2 / 2 h / Ambient temperature
2: 1.) n-BuLi / 1.) HMPA, THF, -20 deg C, 2 h; 2.) HMPA, THF, -20 deg C, 2 h
3: IBX / dimethylsulfoxide; tetrahydrofuran / 5 h / Ambient temperature
4: tetrahydrofuran; diethyl ether / 1 h / Ambient temperature
5: 64 percent / BCl3, 1,3-propanedithiol / CH2Cl2 / 1 h / Ambient temperature
6: 63 percent / PPTS / CH2Cl2 / 48 h / Ambient temperature
With
1.3-propanedithiol; n-butyllithium; pyridinium p-toluenesulfonate; boron trichloride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(98)00619-4
- Guidance literature:
-
Multi-step reaction with 7 steps
1: NaBH4 / methanol / 0.5 h / 0 °C
2: 96 percent / Et3N / CH2Cl2 / 2 h / Ambient temperature
3: 1.) n-BuLi / 1.) HMPA, THF, -20 deg C, 2 h; 2.) HMPA, THF, -20 deg C, 2 h
4: IBX / dimethylsulfoxide; tetrahydrofuran / 5 h / Ambient temperature
5: tetrahydrofuran; diethyl ether / 1 h / Ambient temperature
6: 64 percent / BCl3, 1,3-propanedithiol / CH2Cl2 / 1 h / Ambient temperature
7: 63 percent / PPTS / CH2Cl2 / 48 h / Ambient temperature
With
1.3-propanedithiol; sodium tetrahydroborate; n-butyllithium; pyridinium p-toluenesulfonate; boron trichloride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(98)00619-4
