5-bromo-pentanoic acid 3-(7-chloro-quinolin-4-ylamino)-5-(2-piperidin-1-yl-acetylamino)-benzyl ester

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Chemical Name:5-bromo-pentanoic acid 3-(7-chloro-quinolin-4-ylamino)-5-(2-piperidin-1-yl-acetylamino)-benzyl ester
CAS No.:362054-31-7
Molecular Formula:C₂₈H₃₂BrClN₄O₃
Molecular Weight:587.944
Hs Code.:

Synonyms:5-bromo-pentanoic acid 3-(7-chloro-quinolin-4-ylamino)-5-(2-piperidin-1-yl-acetylamino)-benzyl ester

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Chemical Property of 5-bromo-pentanoic acid 3-(7-chloro-quinolin-4-ylamino)-5-(2-piperidin-1-yl-acetylamino)-benzyl ester

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Technology Process of 5-bromo-pentanoic acid 3-(7-chloro-quinolin-4-ylamino)-5-(2-piperidin-1-yl-acetylamino)-benzyl ester

There total 4 articles about 5-bromo-pentanoic acid 3-(7-chloro-quinolin-4-ylamino)-5-(2-piperidin-1-yl-acetylamino)-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 2067-33-6
5-bromopentanoic acid

: 362054-04-4
N-[3-(7-chloro-quinolin-4-ylamino)-5-hydroxymethyl-phenyl]-2-piperidin-1-yl-acetamide

: 362054-31-7
5-bromo-pentanoic acid 3-(7-chloro-quinolin-4-ylamino)-5-(2-piperidin-1-yl-acetylamino)-benzyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm010842o

Reference yield:

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 362054-31-7
5-bromo-pentanoic acid 3-(7-chloro-quinolin-4-ylamino)-5-(2-piperidin-1-yl-acetylamino)-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / N-methylmorpholine / ethanol; CHCl₃ / 74 h / 0 - 20 °C

2.1: PyBroP; 1-ethylpiperidine / dimethylformamide / 12 h / 20 °C

2.2: 91 percent / dimethylformamide / 5 h / Heating

3.1: 36 percent / DCC; DMAP / CH₂Cl₂ / 18 h / 20 °C

With 1-ethyl-piperidine; 4-methyl-morpholine; dmap; dicyclohexyl-carbodiimide; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm010842o

Reference yield:

: 28150-15-4
3,5-diaminobenzyl alcohol dihydrochloride

: 362054-31-7
5-bromo-pentanoic acid 3-(7-chloro-quinolin-4-ylamino)-5-(2-piperidin-1-yl-acetylamino)-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / N-methylmorpholine / ethanol; CHCl₃ / 74 h / 0 - 20 °C

2.1: PyBroP; 1-ethylpiperidine / dimethylformamide / 12 h / 20 °C

2.2: 91 percent / dimethylformamide / 5 h / Heating

3.1: 36 percent / DCC; DMAP / CH₂Cl₂ / 18 h / 20 °C

With 1-ethyl-piperidine; 4-methyl-morpholine; dmap; dicyclohexyl-carbodiimide; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm010842o