(2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(trimethylsilyloxy)acetonitrile

Base Information

• Chemical Name: (2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(trimethylsilyloxy)acetonitrile
• CAS No.: 861942-74-7
• Molecular Formula: C₁₈H₂₁NO₂SSi
• Molecular Weight: 343.522
• Mol file: 861942-74-7.mol

Synonyms:(2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(trimethylsilyloxy)acetonitrile

Chemical Property of (2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(trimethylsilyloxy)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(trimethylsilyloxy)acetonitrile

There total 1 articles about (2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(trimethylsilyloxy)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)‐2‐(p‐tolylsulfinyl)benzaldehyde (861942-71-4) + trimethylsilyl cyanide (7677-24-9) → (2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(trimethylsilyloxy)acetonitrile (861942-74-7)

Guidance literature:

With ytterbium(III) triflate; In dichloromethane; at -20 ℃; for 24h;

DOI:10.1016/j.tetasy.2005.04.031

Reference yield: 34.0%

(2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(trimethylsilyloxy)acetonitrile (861942-74-7) + methyl iodide (74-88-4) → (S)-1-[2-(p-tolylsulfinyl)phenyl]ethanone

Guidance literature:

(2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(trimethylsilyloxy)acetonitrile; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; toluene; at -78 ℃; for 2h;

DOI:10.1021/jo051029u

Reference yield:

(2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(trimethylsilyloxy)acetonitrile (861942-74-7) → (2R,(S)S)-2-hydroxy-2-[2-(p-tolylsulfinyl)phenyl]acetonitrile (861942-72-5)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1016/j.tetasy.2005.04.031

upstream raw materials:

(S)‐2‐(p‐tolylsulfinyl)benzaldehyde

trimethylsilyl cyanide

Downstream raw materials:

(2R,(S)S)-2-hydroxy-2-[2-(p-tolylsulfinyl)phenyl]acetonitrile

(2R)-mandelamide