2'-chloro-1-((1-(2-fluoro-6-methoxyphenyl)-3-methyl-1H-pyrazol-4-yl)methyl)-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]

Base Information

Chemical Name:2'-chloro-1-((1-(2-fluoro-6-methoxyphenyl)-3-methyl-1H-pyrazol-4-yl)methyl)-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]
CAS No.:1307313-67-2
Molecular Formula:C₂₃H₂₃ClF₃N₃O₂S
Molecular Weight:497.969
Hs Code.:

Synonyms:2'-chloro-1-((1-(2-fluoro-6-methoxyphenyl)-3-methyl-1H-pyrazol-4-yl)methyl)-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]

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Chemical Property of 2'-chloro-1-((1-(2-fluoro-6-methoxyphenyl)-3-methyl-1H-pyrazol-4-yl)methyl)-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]

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Technology Process of 2'-chloro-1-((1-(2-fluoro-6-methoxyphenyl)-3-methyl-1H-pyrazol-4-yl)methyl)-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]

There total 11 articles about 2'-chloro-1-((1-(2-fluoro-6-methoxyphenyl)-3-methyl-1H-pyrazol-4-yl)methyl)-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1307248-58-3
2-chloro-4,4-difluoro-1'-[(3-methyl-1H-pyrazol-4-yl)methyl]-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

: 7079-54-1
1-fluoro-2-iodo-3-methoxybenzene

: 1307313-67-2
2'-chloro-1-((1-(2-fluoro-6-methoxyphenyl)-3-methyl-1H-pyrazol-4-yl)methyl)-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]

Guidance literature:: With copper(I) oxide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1283095-47-5
4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran]

: 1307313-67-2
2'-chloro-1-((1-(2-fluoro-6-methoxyphenyl)-3-methyl-1H-pyrazol-4-yl)methyl)-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid; sulfuryl dichloride / tert-butyl methyl ether / 21.17 h / 15 - 22 °C

2.1: dmap; triethylamine / dichloromethane / 20 °C

3.1: N-Bromosuccinimide / chlorobenzene / 19 h / 20 - 45 °C / Irradiation

4.1: sodium hydrogencarbonate; dimethyl sulfoxide / chlorobenzene / 24 h / 20 °C

5.1: sodium hydrogencarbonate; sodium hypochlorite; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; chlorobenzene; water / 2 h / 5 - 20 °C

6.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran / 24 h / 70 °C

7.1: hydrogenchloride / isopropyl alcohol; water / 15 h / 45 °C

8.1: tetrahydrofuran / 1 h / 20 °C

8.2: 15 h / 20 °C

8.3: Cooling

9.1: copper(I) oxide; caesium carbonate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl-formamide / 16 h / 110 °C / Inert atmosphere

With copper(I) oxide; hydrogenchloride; dmap; sodium hypochlorite; N-Bromosuccinimide; sulfuryl dichloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium hydrogencarbonate; caesium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; potassium bromide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; chlorobenzene; isopropyl alcohol;

Reference yield:

: 1307248-40-3
4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-ium trifluoroacetate

: 1307313-67-2
2'-chloro-1-((1-(2-fluoro-6-methoxyphenyl)-3-methyl-1H-pyrazol-4-yl)methyl)-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide / dichloromethane; water / Cooling with ice

2.1: acetic acid; sulfuryl dichloride / tert-butyl methyl ether / 21.17 h / 15 - 22 °C

3.1: dmap; triethylamine / dichloromethane / 20 °C

4.1: N-Bromosuccinimide / chlorobenzene / 19 h / 20 - 45 °C / Irradiation

5.1: sodium hydrogencarbonate; dimethyl sulfoxide / chlorobenzene / 24 h / 20 °C

6.1: sodium hydrogencarbonate; sodium hypochlorite; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; chlorobenzene; water / 2 h / 5 - 20 °C

7.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran / 24 h / 70 °C

8.1: hydrogenchloride / isopropyl alcohol; water / 15 h / 45 °C

9.1: tetrahydrofuran / 1 h / 20 °C

9.2: 15 h / 20 °C

9.3: Cooling

10.1: copper(I) oxide; caesium carbonate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl-formamide / 16 h / 110 °C / Inert atmosphere

With copper(I) oxide; hydrogenchloride; dmap; sodium hypochlorite; N-Bromosuccinimide; sulfuryl dichloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium hydrogencarbonate; caesium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; potassium bromide; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; chlorobenzene; isopropyl alcohol;