C₁₉H₁₀ClFO₃

Base Information

• Chemical Name: C₁₉H₁₀ClFO₃
• CAS No.: 1431734-62-1
• Molecular Formula: C₁₉H₁₀ClFO₃
• Molecular Weight: 340.738
• Mol file: 1431734-62-1.mol

Synonyms:C₁₉H₁₀ClFO₃

Chemical Property of C₁₉H₁₀ClFO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₀ClFO₃

There total 5 articles about C₁₉H₁₀ClFO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H14ClFO3 (1603880-98-3) → C19H10ClFO3 (1431734-62-1)

Guidance literature:

With sodium hydroxide; In methanol; water; for 2h; Reflux;

DOI:10.1248/cpb.c13-00486

Reference yield:

1-hydroxy-2-naphthaldehyde (574-96-9) → C19H10ClFO3 (1431734-62-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 15 h / Reflux

2: bromine / dichloromethane / 1 h / 20 °C

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; methanol / 2 h / Reflux

4: sodium hydroxide / methanol; water / 2 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; water; toluene; acetonitrile; 3: |Suzuki Coupling;

DOI:10.1248/cpb.c13-00486

Reference yield:

ethyl naphthol<1,2-b>furan-2-carboxylate (74222-20-1) → C19H10ClFO3 (1431734-62-1)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / dichloromethane / 1 h / 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; methanol / 2 h / Reflux

3: sodium hydroxide / methanol; water / 2 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; sodium hydroxide; In methanol; dichloromethane; water; toluene; 2: |Suzuki Coupling;

DOI:10.1248/cpb.c13-00486

upstream raw materials:

1-hydroxy-2-naphthaldehyde

ethyl naphthol<1,2-b>furan-2-carboxylate

α-naphthol

ethyl 5-bromonaphtho[1,2-b]furan-2-carboxylate

Downstream raw materials:

N-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-5-(3-chloro-4-fluorophenyl)naphtho[1,2-b]furan-2-carboxamide