1-Hydroxy-2-naphthaldehyde

Base Information

• Chemical Name: 1-Hydroxy-2-naphthaldehyde
• CAS No.: 574-96-9
• Molecular Formula: C11H8O2
• Molecular Weight: 172.183
• Hs Code.: 2912499000
• European Community (EC) Number: 679-991-2
• DSSTox Substance ID: DTXSID70332062
• Nikkaji Number: J2.385.173C,J534.105A
• Wikidata: Q27103496
• Metabolomics Workbench ID: 69671
• Mol file: 574-96-9.mol

Synonyms:1-hydroxy-2-naphthaldehyde

Chemical Property of 1-Hydroxy-2-naphthaldehyde

Chemical Property:

• Melting Point: 56 °C
• Boiling Point: 317 °C at 760 mmHg
• PKA: 8.37±0.50(Predicted)
• Flash Point: 134.3 °C
• PSA: 37.30000
• Density: 1.288 g/cm³
• LogP: 2.35790
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 172.052429494
• Heavy Atom Count: 13
• Complexity: 191

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Hydroxy-2-naphthaldehyde ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38-52
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=C2O)C=O
• Uses: 1-Hydroxy-2-naphthaldehyde is used as a reagent in the synthesis of naphthofurancarboxamides as melanin concentrating hormone receptor 1 antagonists. Also used as a reagent in the synthesis of hydropyridinylphenoxyacetohydrazones which show anticonvulsant, anti-inflammatory, and analgesic activity.

Technology Process of 1-Hydroxy-2-naphthaldehyde

There total 5 articles about 1-Hydroxy-2-naphthaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

α-naphthol (90-15-3) + Dichloromethyl methyl ether (4885-02-3) → 1-hydroxy-2-naphthaldehyde (574-96-9) + 4-hydroxy-1-naphthaldehyde (7770-45-8)

Guidance literature:

With titanium tetrachloride; In dichloromethane; for 1.5h; Ambient temperature;

Reference yield: 10.0%

ethyl (E)-3-(naphthalen-1-yl)-2-nitroacrylate (60859-75-8) → 1-hydroxy-2-naphthaldehyde (574-96-9) + Ethyl oxamate (617-36-7) + ethyl naphthol<1,2-b>furan-2-carboxylate (74222-20-1) + 2-(ethoxyoxalylaminomethylene)naphthalen-1-one (88472-35-9)

Guidance literature:

In acetone; at 20 ℃; for 2h; Further byproducts given; Irradiation;

Reference yield: 10.0%

ethyl (E)-3-(naphthalen-1-yl)-2-nitroacrylate (60859-75-8) → 1-hydroxy-2-naphthaldehyde (574-96-9) + Ethyl oxamate (617-36-7) + ethyl 3-(1-naphthyl)-3-oximino-2-oxopropionate (74222-18-7) + 2-(ethoxyoxalylaminomethylene)naphthalen-1-one (88472-35-9)

Guidance literature:

In acetone; at 20 ℃; for 2h; Further byproducts given; Irradiation;

upstream raw materials:

ethyl (E)-3-(naphthalen-1-yl)-2-nitroacrylate

α-naphthol

Dichloromethyl methyl ether

N,N-dimethyl-formamide

Downstream raw materials:

2-methylnaphthalen-1-ol

C₂₃H₁₉NO₃

3-benzyl-7,8-benzocoumarin

1-Hydroxy-naphthaldehyd-⁽²⁾-benzyloxy-thiocarbonyl-hydrazon