400648-58-0Relevant academic research and scientific papers
Reductive monoalkylation of nitro aryls in one-pot
Sydnes, Magne O.,Kuse, Masaki,Isobe, Minoru
, p. 6406 - 6414 (2008/09/21)
The scope of the serendipitous reductive monoalkylation of ethyl (4-methoxy-3-nitrophenyl) acetate taking place during reduction of the nitro functionality to the corresponding primary amine when treated with hydrogen (1 atm) over Pd/C (10%) in ethanol is investigated. Upon prolonged reaction time the reaction conducted in ethanol and methanol yields significant amount of the corresponding secondary amines, while when performed in n-butanol and i-propanol it only resulted in the formation of a small amount of the corresponding secondary amines. Further development of the reductive monoalkylation reaction provided conditions that facilitate conversion of a range of different nitro aryls in one-pot to the corresponding secondary benzyl amino aryls in mostly good to excellent yields. This is accomplished by using hydrogen (1 atm) over Pd/C (10%) as reducing agent and benzaldehyde as the benzyl source combined with a stepwise reaction sequence. This chemistry was further extended to the formation of substituted benzyl amino aryls. The yields of the latter products varied dramatically depending on the substitution patterns associated with the benzaldehyde. However, by altering the reaction conditions it was possible to improve the yields of the benzylated products.
One-pot reductive monoalkylation of nitro aryls with hydrogen over Pd/C
Sydnes, Magne O.,Isobe, Minoru
, p. 1199 - 1202 (2008/09/17)
A range of different nitro aryls were converted in one-pot to the corresponding secondary alkyl amino aryls in good to excellent yields by using aldehydes as alkyl source and hydrogen over Pd/C (10%) as reducing agent. In all examples, but one, the second
2,3-Diphenylpropionic acids as potent VLA-4 antagonists
Hoshina, Yoichiro,Ikegami, Satoru,Okuyama, Akihiko,Fukui, Hideto,Inoguchi, Kiyoshi,Maruyama, Tatsuya,Fujimoto, Kyoko,Matsumura, Yuzuru,Aoyama, Akinori,Harada, Tatsuhiro,Tanaka, Hiroshi,Nakamura, Tsutomu
, p. 217 - 220 (2007/10/03)
2,3-Diphenylpropionic acid derivatives as highly potent VLA-4 antagonists are described. One representative compound, 9cc has inhibited intercellular adhesion by a VCAM-1/VLA-4 interaction with an IC50 of 1.7 nM, and has good pharmacokinetics a
2,3-DIPHENYLPROPIONIC ACID DERIVATIVES OR THEIR SALTS, MEDICINES OR CELL ADHESION INHIBITORS CONTAINING THE SAME, AND THEIR USAGE
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, (2008/06/13)
A 2,3-diphenylpropionic acid derivatives or the salts represented by general formula (1) below; and pharmaceutical compositions and cell adhesion inhibitors comprising the derivatives or the salts as the active ingredient. In the formula, A, B and C indep
