trans-Benzyl 3-((tert-butoxycarbonyl)amino)-4-fluoropiperidine-1-carboxylate

Base Information

Chemical Name:trans-Benzyl 3-((tert-butoxycarbonyl)amino)-4-fluoropiperidine-1-carboxylate
CAS No.:1052713-39-9
Molecular Formula:C₁₈H₂₅FN₂O₄
Molecular Weight:352.406
Hs Code.:

Synonyms:trans-Benzyl 3-((tert-butoxycarbonyl)amino)-4-fluoropiperidine-1-carboxylate;1052713-40-2;(3S,4S)-benzyl 3-((tert-butoxycarbonyl)amino)-4-fluoropiperidine-1-carboxylate;trans-Benzyl3-((tert-butoxycarbonyl)amino)-4-fluoropiperidine-1-carboxylate

Suppliers and Price of trans-Benzyl 3-((tert-butoxycarbonyl)amino)-4-fluoropiperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of trans-Benzyl 3-((tert-butoxycarbonyl)amino)-4-fluoropiperidine-1-carboxylate

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:352.17983545
Heavy Atom Count:25
Complexity:461

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CN(CCC1F)C(=O)OCC2=CC=CC=C2
Isomeric SMILES:CC(C)(C)OC(=O)N[C@H]1CN(CC[C@@H]1F)C(=O)OCC2=CC=CC=C2

Technology Process of trans-Benzyl 3-((tert-butoxycarbonyl)amino)-4-fluoropiperidine-1-carboxylate

There total 7 articles about trans-Benzyl 3-((tert-butoxycarbonyl)amino)-4-fluoropiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1214242-81-5
(3R,4R)-benzyl 3-(tert-butoxycarbonylamino)-4-fluoropiperidine-1-carboxylate

: 1052713-38-8
benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate

: 1052713-39-9
(3S,4S)-benzyl 3-(tert-butoxycarbonylamino)-4-fluoropiperidine-1-carboxylate

Guidance literature:: With CHIRALPAK AS; In n-heptane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: benzyl 3-((tert-butoxycarbonyl)amino)-4-fluoropiperidine-1-carboxylate

: 1052713-38-8
benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate

: 1052713-39-9
(3S,4S)-benzyl 3-(tert-butoxycarbonylamino)-4-fluoropiperidine-1-carboxylate

Guidance literature:: With Chiralpak AS; In n-heptane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 66207-08-7,1624258-63-4
3,4-epoxy-piperidine-1-carboxylic acid benzyl ester

: 1052713-38-8
benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate

: 1052713-39-9
(3S,4S)-benzyl 3-(tert-butoxycarbonylamino)-4-fluoropiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium hydroxide; water / ethanol / 5 h / 70 °C

1.2: 2 h / 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane; water / 15 h / -78 - 20 °C

3.1: Chiralpak AS / isopropyl alcohol; n-heptane / Resolution of racemate

With ammonium hydroxide; diethylamino-sulfur trifluoride; water; In ethanol; n-heptane; dichloromethane; water; isopropyl alcohol;