C₂₄H₂₈BrNO₄S

Base Information

• Chemical Name: C₂₄H₂₈BrNO₄S
• CAS No.: 1309881-88-6
• Molecular Formula: C₂₄H₂₈BrNO₄S
• Molecular Weight: 506.461
• Mol file: 1309881-88-6.mol

Synonyms:C₂₄H₂₈BrNO₄S

Chemical Property of C₂₄H₂₈BrNO₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₈BrNO₄S

There total 3 articles about C₂₄H₂₈BrNO₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester (1309881-44-4) → C24H28BrNO4S (1309881-88-6)

Guidance literature:

With diisobutylaluminium hydride; In hexane; benzene; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201007727

Reference yield:

N,N-bis(2-butynyl)-(4-bromophenyl)sulfonamide (887266-64-0) → C24H28BrNO4S (1309881-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / hexane; benzene / 2 h / 20 °C / Inert atmosphere

With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; diisobutylaluminium hydride; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; In hexane; dichloromethane; benzene;

DOI:10.1002/anie.201007727

Reference yield:

ethyl 2-benzoylpropionate (10488-87-6) → C24H28BrNO4S (1309881-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / hexane; benzene / 2 h / 20 °C / Inert atmosphere

With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; diisobutylaluminium hydride; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; In hexane; dichloromethane; benzene;

DOI:10.1002/anie.201007727

upstream raw materials:

N,N-bis(2-butynyl)-(4-bromophenyl)sulfonamide

(S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester

ethyl 2-benzoylpropionate

Downstream raw materials:

(S)-3-hydroxy-2-methyl-1-phenylpropan-1-one

(R)-3-hydroxy-2-methyl-1-phenylpropan-1-one

C₃₆H₅₆BrNO₄SSi₂

(R)-3-(tert-butyldimethylsilyloxy)-2-methyl-1-phenylpropan-1-one