methyl 3-[(4-methoxyphenyl)ethynyl]-4-[(trimethylsilyl)-ethynyl]benzoate

Base Information

Chemical Name:methyl 3-[(4-methoxyphenyl)ethynyl]-4-[(trimethylsilyl)-ethynyl]benzoate
CAS No.:1378284-27-5
Molecular Formula:C₂₂H₂₂O₃Si
Molecular Weight:362.5
Hs Code.:

Synonyms:methyl 3-[(4-methoxyphenyl)ethynyl]-4-[(trimethylsilyl)-ethynyl]benzoate

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Chemical Property of methyl 3-[(4-methoxyphenyl)ethynyl]-4-[(trimethylsilyl)-ethynyl]benzoate

Chemical Property:

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Technology Process of methyl 3-[(4-methoxyphenyl)ethynyl]-4-[(trimethylsilyl)-ethynyl]benzoate

There total 5 articles about methyl 3-[(4-methoxyphenyl)ethynyl]-4-[(trimethylsilyl)-ethynyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1150112-11-0
methyl 3-bromo-4-[(trimethylsilyl)ethynyl]benzoate

: 768-60-5
4-methoxyphenylacetylen

: 1378284-27-5
methyl 3-[(4-methoxyphenyl)ethynyl]-4-[(trimethylsilyl)-ethynyl]benzoate

Guidance literature:: With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; diisopropylamine; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jo300771f

Reference yield:

: 6311-37-1
4-amino-3-bromo-benzoic acid

: 1378284-27-5
methyl 3-[(4-methoxyphenyl)ethynyl]-4-[(trimethylsilyl)-ethynyl]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 20 h / Reflux

2.1: hydrogenchloride; sodium nitrite / water / 1.25 h / 0 °C

2.2: 24 h / 0 - 20 °C / Darkness

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

4.1: copper(l) iodide; bis(benzonitrile)palladium(ll) chloride; tri-tert-butyl phosphine; diisopropylamine / toluene / 7 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(benzonitrile)palladium(ll) chloride; tri-tert-butyl phosphine; sulfuric acid; triethylamine; diisopropylamine; sodium nitrite; In tetrahydrofuran; water; toluene;
DOI:10.1039/c2ob25298h

Reference yield:

: 106896-49-5
methyl 4-amino-3-bromobenzoate

: 1378284-27-5
methyl 3-[(4-methoxyphenyl)ethynyl]-4-[(trimethylsilyl)-ethynyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 1.25 h / 0 °C

1.2: 24 h / 0 - 20 °C / Darkness

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: copper(l) iodide; bis(benzonitrile)palladium(ll) chloride; tri-tert-butyl phosphine; diisopropylamine / toluene / 7 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(benzonitrile)palladium(ll) chloride; tri-tert-butyl phosphine; triethylamine; diisopropylamine; sodium nitrite; In tetrahydrofuran; water; toluene;
DOI:10.1039/c2ob25298h