(E)-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-3-p-tolylacrylamide

Base Information

Chemical Name:(E)-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-3-p-tolylacrylamide
CAS No.:1186073-39-1
Molecular Formula:C₂₆H₂₃N₅O
Molecular Weight:421.502
Hs Code.:

Synonyms:(E)-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-3-p-tolylacrylamide

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Chemical Property of (E)-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-3-p-tolylacrylamide

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Technology Process of (E)-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-3-p-tolylacrylamide

There total 4 articles about (E)-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-3-p-tolylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.4%

: 15851-89-5,13565-07-6
(E)-p-methylcinnamoyl chloride

: 152460-10-1
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

: 1186073-39-1
(E)-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-3-p-tolylacrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.2174/1570180811666140812231519

Reference yield:

: 13565-07-6,15851-89-5
4-methylcinnamoyl chloride

: 152460-10-1
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

: 1186073-39-1
(E)-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-3-p-tolylacrylamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃;
DOI:10.3390/molecules14104166

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 1186073-39-1
(E)-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-3-p-tolylacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; piperidine / 90 °C

2: oxalyl dichloride / dichloromethane / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

With piperidine; pyridine; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.2174/1570180811666140812231519