3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6-(3-methylmorpholino)-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran

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Chemical Name:3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6-(3-methylmorpholino)-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran
CAS No.:1360882-70-7
Molecular Formula:C₄₂H₄₀FNO₅
Molecular Weight:657.782
Hs Code.:

Synonyms:3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6-(3-methylmorpholino)-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran

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Chemical Property of 3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6-(3-methylmorpholino)-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran

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Technology Process of 3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6-(3-methylmorpholino)-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran

There total 7 articles about 3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6-(3-methylmorpholino)-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42185-06-8
3-methylmorpholine

: 1240374-37-1
3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6,11-difluoro-13,13-dimethyl-3H,13H-indeno[2',3':3,4]naphtho[1,2-b]pyran

: 1360882-70-7
3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6-(3-methylmorpholino)-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran

Guidance literature:: 3-methylmorpholine; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 0.5h; Inert atmosphere;

3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6,11-difluoro-13,13-dimethyl-3H,13H-indeno[2',3':3,4]naphtho[1,2-b]pyran; In tetrahydrofuran; hexane; at 20 ℃; for 24h; Inert atmosphere;

Reference yield:

: 122-99-6,56257-90-0,9004-78-8
2-Phenoxyethanol

: 1360882-70-7
3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6-(3-methylmorpholino)-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 23 °C / Cooling with ice

2.1: tin(IV) chloride / dichloromethane / 2 h / 15 - 20 °C

3.1: sodium hydroxide; ethanol / 1 h / Reflux

4.1: N,N-dimethyl-formamide; xylene / 1 h / 23 °C / Cooling with ice

5.1: toluene-4-sulfonic acid / dichloromethane / 70 h / 20 °C

6.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

6.2: 24 h / 20 °C / Inert atmosphere

With n-butyllithium; ethanol; tin(IV) chloride; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; xylene;

Reference yield:

: 1360882-67-2
4-methoxy-4'-(2-acetoxyethoxy)benzophenone

: 1360882-70-7
3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6-(3-methylmorpholino)-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; ethanol / 1 h / Reflux

2.1: N,N-dimethyl-formamide; xylene / 1 h / 23 °C / Cooling with ice

3.1: toluene-4-sulfonic acid / dichloromethane / 70 h / 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

4.2: 24 h / 20 °C / Inert atmosphere

With n-butyllithium; ethanol; toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; xylene;