4-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)butyric acid

Base Information

• Chemical Name: 4-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)butyric acid
• CAS No.: 1311295-94-9
• Molecular Formula: C₁₉H₂₉NO₃
• Molecular Weight: 319.444
• Mol file: 1311295-94-9.mol

Synonyms:4-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)butyric acid

Chemical Property of 4-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)butyric acid

There total 2 articles about 4-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + 3-benzyl propionaldehyde (18328-11-5) → 4-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)butyric acid (1311295-94-9)

Guidance literature:

With laccase; at 20 ℃; for 5h; pH=4.4; optical yield given as %ee; enantioselective reaction; aq. acetate buffer; Under air; Enzymatic reaction;

DOI:10.1021/ol2012956

Reference yield:

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + 3-benzyl propionaldehyde (18328-11-5) → 4-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)butyric acid (1333428-88-8) + 4-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)butyric acid (1311295-94-9) + 4-Phenylbutyric acid (1821-12-1)

Guidance literature:

With laccase; (5R)-(+)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride; In water; at 20 ℃; for 5h; optical yield given as %ee; enantioselective reaction; Air;

DOI:10.1021/ol2012956

Reference yield:

4-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)butyric acid (1311295-94-9) → (S)-3-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxyl)propan-1-ol (936331-31-6)

Guidance literature:

With borane-THF; In tetrahydrofuran; for 0.5h;

DOI:10.1021/ol2012956

upstream raw materials:

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

3-benzyl propionaldehyde

Downstream raw materials:

(S)-3-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxyl)propan-1-ol