N-(3-(2-bromophenyl)propyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide

Base Information

Chemical Name:N-(3-(2-bromophenyl)propyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide
CAS No.:1310552-84-1
Molecular Formula:C₁₆H₁₉BrF₃NOSi
Molecular Weight:406.318
Hs Code.:

Synonyms:N-(3-(2-bromophenyl)propyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(2-bromophenyl)propyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide

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Technology Process of N-(3-(2-bromophenyl)propyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide

There total 5 articles about N-(3-(2-bromophenyl)propyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1310552-75-0
N-(3-(2-bromophenyl)propyl)-2,2,2-trifluoroacetamide

: (2-(trimethylsilyl)ethynyl)(phenyl)iodonium trifluoromethanesulfonate

: 1310552-84-1
N-(3-(2-bromophenyl)propyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide

Guidance literature:: With potassium hexamethylsilazane; In toluene; at 20 - 80 ℃; for 2.5h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.03.118

Reference yield:

: 55223-26-2
3-(2-bromophenyl)propanamide

: 1310552-84-1
N-(3-(2-bromophenyl)propyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 0 °C / Inert atmosphere; Reflux

2: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: potassium hexamethylsilazane / toluene / 2.5 h / 20 - 80 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; potassium hexamethylsilazane; acetic acid; In 1,4-dioxane; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2011.03.118

Reference yield:

: 65185-60-6
3-(2-bromophenyl)propan-1-amine

: 1310552-84-1
N-(3-(2-bromophenyl)propyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: potassium hexamethylsilazane / toluene / 2.5 h / 20 - 80 °C / Inert atmosphere

With pyridine; potassium hexamethylsilazane; In dichloromethane; toluene;
DOI:10.1016/j.tetlet.2011.03.118