3-(2-broMophenyl)propan-1-aMine

Base Information

• Chemical Name: 3-(2-broMophenyl)propan-1-aMine
• CAS No.: 65185-60-6
• Molecular Formula: C9H12BrN
• Molecular Weight: 214.105
• Mol file: 65185-60-6.mol

Synonyms:3-(2-broMophenyl)propan-1-aMine;2-BroMo-benzenepropanaMine;3-(2-BroMophenyl)-1-propanaMine

Chemical Property of 3-(2-broMophenyl)propan-1-aMine

Chemical Property:

• PSA: 26.02000
• LogP: 3.04070

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-Bromophenyl)-1-propanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-broMophenyl)propan-1-aMine

There total 9 articles about 3-(2-broMophenyl)propan-1-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(2-bromophenyl)propanamide (55223-26-2) → 3-(2-bromophenyl)propan-1-amine (65185-60-6)

Guidance literature:

With sodium tetrahydroborate; acetic acid; In 1,4-dioxane; at 0 ℃; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2011.03.118

Reference yield: 84.0%

3-(2-bromo-phenyl)-propionitrile (61698-07-5) → 3-(2-bromophenyl)propan-1-amine (65185-60-6)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether; for 18h;

DOI:10.1016/0040-4020(96)00266-9

Reference yield: 39.0%

N-trimethylsilylmethylamine (18166-02-4) + 2-bromostyrene (2039-88-5) → 3-(2-bromophenyl)propan-1-amine (65185-60-6) + (RS)-3-(2-bromophenyl)-1-(trimethylsilyl)propan-1-amine

Guidance literature:

With 3,5-difluoro-2,4,6-tris(N-phenylanilino)benzonitrile; tetrabutylammoniun azide; In N,N-dimethyl-formamide; at 25 - 26 ℃; for 20h; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1021/jacs.1c07401

upstream raw materials:

3-(2-bromophenyl)propanamide

3-(2-bromo-phenyl)-propionitrile

1-Bromo-2-iodobenzene

3-(2-bromo-phenyl)-acrylonitrile

Refernces

• 1、 Kiyokawa, Kensuke,Nakamura, Shogo,Jou, Keisuke,Iwaida, Kohji,Minakata, Satoshi. "Transition-metal-free Intramolecular C-H amination of sulfamate esters and: N -alkylsulfamides". supporting information. p. 11782 - 11785. Retrieved 2019/10/02.
• 2、 Balieu, Sébastien,Toutah, Krimo,Carro, Laura,Chamoreau, Lise-Marie,Rousselière, Hélène,Courillon, Christine. "Radical cyclization of ynamides into six- or eight-membered rings. Application to the synthesis of a protoberberine analog". supporting information; experimental part. p. 2876 - 2880. Retrieved 2011/06/21.