55223-26-2Relevant academic research and scientific papers
The Asymmetric Synthesis of 1-Alkyl-2,3,4,5-Tetrahydro-Benzazepines and Benzo-1-AzabicycloDecanes
Meyers, A. I.,Hutchings, Richard H.
, p. 1807 - 1820 (1993)
The metalation-alkylation of benzazepine formamidines gives high yields and good diastereoselectivity of 1-substituted derivatives.Removal of the chiral auxiliary leads to the title compounds in 84-96 percent ee and represents the first chiral benzazepine
Primary fatty acid amide preparation method
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Paragraph 0364-0366, (2018/10/19)
The present invention provides a primary fatty acid amide preparation method. According to the present invention, under the action of a single auxiliary agent phosphine-containing transition metal catalyst or a combined auxiliary agent comprising a phosphine-free transition metal catalyst and a phosphine-containing ligand, terminally substituted olefin or cyclo-olefin, carbon monoxide and an ammonium salt are subjected to a hydrogen carboamidation reaction so as to prepare the primary fatty acid amide compound in one step; the raw material and the catalyst of the reaction are inexpensive and easy to obtain, and the synthesis process is simple, such that the synthesis cost is substantially reduced; the preparation method has characteristics of mild reaction condition and high yield, and issuitable for industrial production; and the raw material and the catalyst of the reaction are clean, non-toxic and low environment pollution.
Synthesis and reactivity of ortho-palladated 3-phenylpropanamides. Insertion of CO, XyNC, and alkynes into the Pd-C bond. Synthesis of seven-and nine-membered palladacycles and benzazepine-and benzazonine-based heterocycles
Frutos-Pedreno, Roberto,Gonzalez-Herrero, Pablo,Vicente, Jose,Jones, Peter G.
supporting information, p. 1892 - 1904 (2013/05/08)
Aryl palladium complexes [Pd{C6H4(CH 2)2C(O)NRR′)-2}I(tmeda)] [NRR′ = NH 2 (1a), NHMe (1b), NMe2 (1c); tmeda = N,N,N′, N′-tetramethylethylenediamine] are prepared by oxidative addition of t
Discovery of TUG-770: A highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes
Christiansen, Elisabeth,Hansen, Steffen V. F.,Urban, Christian,Hudson, Brian D.,Wargent, Edward T.,Grundmann, Manuel,Jenkins, Laura,Zaibi, Mohamed,Stocker, Claire J.,Ullrich, Susanne,Kostenis, Evi,Kassack, Matthias U.,Milligan, Graeme,Cawthorne, Michael A.,Ulven, Trond
supporting information, p. 441 - 445 (2013/07/11)
Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing.
Radical cyclization of ynamides into six- or eight-membered rings. Application to the synthesis of a protoberberine analog
Balieu, Sébastien,Toutah, Krimo,Carro, Laura,Chamoreau, Lise-Marie,Rousselière, Hélène,Courillon, Christine
supporting information; experimental part, p. 2876 - 2880 (2011/06/21)
A straightforward formation of six- and eight-membered rings via the radical cyclization of specifically designed ynamides is reported. This strategy provides a protoberberine analog in only three steps by a radical cyclization cascade.
RENIN INHIBITORS
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Page/Page column 28, (2009/04/25)
The present invention relates to biphenyl compounds of formula (I). These compounds are renin inhibitors of a non- peptidic nature and of low molecular weight. The invention further relates to a pharmaceutical composition containing said compounds, as wel
