(R)-tert-butyl 2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetate

Base Information

Chemical Name:(R)-tert-butyl 2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetate
CAS No.:1228773-88-3
Molecular Formula:C₁₇H₂₃NO₅
Molecular Weight:321.373
Hs Code.:

Synonyms:(R)-tert-butyl 2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl 2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetate

Chemical Property:

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Technology Process of (R)-tert-butyl 2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetate

There total 1 articles about (R)-tert-butyl 2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228773-88-3
(R)-tert-butyl 2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetate

Guidance literature:

Reference yield:

: 1228773-88-3
(R)-tert-butyl 2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetate

: 1228773-89-4
(R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 1h;

Reference yield:

: 1228773-88-3
(R)-tert-butyl 2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetate

: 1616068-86-0
2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-1H-benzo[d]imidazole-6-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 25 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 25 °C

3: acetic acid / 0.33 h / 120 °C / Microwave irradiation

4: acetyl chloride / 48 h / 0 - 25 °C

5: ammonia / methanol / 25 °C

With ammonia; acetic acid; N-ethyl-N,N-diisopropylamine; acetyl chloride; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide;