4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 206879-72-3
• Molecular Formula: C15H23 N3 O2
• Molecular Weight: 277.367
• Hs Code.: 2933599090
• Mol file: 206879-72-3.mol

Synonyms:1-Boc-4-(3-aminophenyl)piperazine;4-(3-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl4-(3-aminophenyl)piperazine-1-carboxylate

Chemical Property of 4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 442.427°C at 760 mmHg
• PKA: 5.35±0.10(Predicted)
• Flash Point: 221.372°C
• PSA: 58.80000
• Density: 1.145
• LogP: 2.91000

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(3-Aminophenyl)-1-piperazinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 4-(3-Aminophenyl)-1-piperazinecarboxylate is used in the synthesis and preparation of 5-amino-1-heterocyclyl-1H-pyrazole derivatives as anti-tumor agents.

Technology Process of 4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 7 articles about 4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

4-(3-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (206879-94-9) → 4-(3-amino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (206879-72-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; water; ethyl acetate; for 3h; under 750.075 Torr;

Reference yield: 94.0%

→ 4-(3-amino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (206879-72-3)

Guidance literature:

Reference yield:

1-(3-nitrophenyl)piperazine (54054-85-2) → 4-(3-amino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (206879-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / dichloromethane / 20 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

With dmap; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;

upstream raw materials:

4-(3-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

3-fluoro-1-nitrobenzene

1-t-Butoxycarbonylpiperazine

di-tert-butyl dicarbonate

Downstream raw materials:

1-[3-ethoxycarbonylamino-phenyl]-4-tert-butoxycarbonyl-piperazine

4-(3-{5-[2-(4-methoxy-phenyl)-vinyl]-thiazol-2-ylamino}-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

4-{3-[4-(4-chloro-3-methoxy-phenylamino)-5-methyl-pyrimidin-2-ylamino]-phenyl}-piperazine-1-carboxylic acid tert butyl ester

4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide

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