methyl 4-(6-(3-ethoxy-4-hydroxy-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)phenylcarbamate

Base Information

Chemical Name:methyl 4-(6-(3-ethoxy-4-hydroxy-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)phenylcarbamate
CAS No.:1283117-99-6
Molecular Formula:C₂₆H₂₄N₄O₇
Molecular Weight:504.499
Hs Code.:

Synonyms:methyl 4-(6-(3-ethoxy-4-hydroxy-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)phenylcarbamate

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Chemical Property of methyl 4-(6-(3-ethoxy-4-hydroxy-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)phenylcarbamate

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Technology Process of methyl 4-(6-(3-ethoxy-4-hydroxy-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)phenylcarbamate

There total 6 articles about methyl 4-(6-(3-ethoxy-4-hydroxy-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.6%

: 1283118-00-2
methyl 4-(6-(3-ethoxy-4-(methoxycarbonyloxy)-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)phenylcarbamate

: 1283117-99-6
methyl 4-(6-(3-ethoxy-4-hydroxy-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)phenylcarbamate

Guidance literature:: methyl 4-(6-(3-ethoxy-4-(methoxycarbonyloxy)-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)phenylcarbamate; With water; sodium hydroxide; In ethanol; at 0 - 28 ℃; for 4h;

With hydrogenchloride; In ethanol; water; pH=5;

Reference yield:

: 2001-29-8
1-(4-bromophenyl)-2-phenyl-ethan-1-one

: 1283117-99-6
methyl 4-(6-(3-ethoxy-4-hydroxy-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethanol; water / Reflux

2.1: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Inert atmosphere; Reflux

3.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 5 h / 0 °C

5.1: sodium hydroxide; water / ethanol / 4 h / 0 - 28 °C

5.2: pH 5

With hydrogenchloride; water; caesium carbonate; triethylamine; sodium hydroxide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 178686-24-3
3-ethoxy-4-hydroxy-5-nitrobenzaldehyde

: 1283117-99-6
methyl 4-(6-(3-ethoxy-4-hydroxy-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethanol; water / Reflux

2.1: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Inert atmosphere; Reflux

3.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 5 h / 0 °C

5.1: sodium hydroxide; water / ethanol / 4 h / 0 - 28 °C

5.2: pH 5

With hydrogenchloride; water; caesium carbonate; triethylamine; sodium hydroxide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;