3-[5-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]thiophene-2-yl]acrylonitrile

Base Information

Chemical Name:3-[5-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]thiophene-2-yl]acrylonitrile
CAS No.:1267605-14-0
Molecular Formula:C₂₄H₃₀N₂OS
Molecular Weight:394.581
Hs Code.:

Synonyms:3-[5-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]thiophene-2-yl]acrylonitrile

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Chemical Property of 3-[5-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]thiophene-2-yl]acrylonitrile

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Technology Process of 3-[5-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]thiophene-2-yl]acrylonitrile

There total 4 articles about 3-[5-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]thiophene-2-yl]acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 1267603-59-7
5-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]thiophene-2-carboaldehyde

: 1267605-14-0
3-[5-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]thiophene-2-yl]acrylonitrile

Guidance literature:: diethyl 1-cyanomethylphosphonate; With sodium hydride; In tetrahydrofuran; for 0.5h; Cooling with ice;

5-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]thiophene-2-carboaldehyde; In tetrahydrofuran; for 1h;

Reference yield:

: N,N-dibutyl-4-amino-2-hydroxy-benzaldehyde

: 1267605-14-0
3-[5-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]thiophene-2-yl]acrylonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 50 °C

2.1: phenyllithium / dibutyl ether; tetrahydrofuran / 1.5 h / Cooling with ice; Inert atmosphere

3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -73 - -70 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.5 h / Cooling with ice

4.2: 1 h

With n-butyllithium; sodium hydride; potassium carbonate; phenyllithium; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dibutyl ether;

Reference yield:

: 103893-16-9
4-N,N-di-n-butylamino-2-methoxybenzaldehyde

: 1267605-14-0
3-[5-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]thiophene-2-yl]acrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: phenyllithium / dibutyl ether; tetrahydrofuran / 1.5 h / Cooling with ice; Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -73 - -70 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.5 h / Cooling with ice

3.2: 1 h

With n-butyllithium; sodium hydride; phenyllithium; In tetrahydrofuran; hexane; dibutyl ether;