O-(5-(3-amino-4-fluorophenoxy)pyridin-2-yl)methyl S-methyl carbonodithioate

Base Information

• Chemical Name: O-(5-(3-amino-4-fluorophenoxy)pyridin-2-yl)methyl S-methyl carbonodithioate
• CAS No.: 1025456-64-7
• Molecular Formula: C₁₄H₁₃FN₂O₂S₂
• Molecular Weight: 324.4
• Mol file: 1025456-64-7.mol

Synonyms:O-(5-(3-amino-4-fluorophenoxy)pyridin-2-yl)methyl S-methyl carbonodithioate

Chemical Property of O-(5-(3-amino-4-fluorophenoxy)pyridin-2-yl)methyl S-methyl carbonodithioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-(5-(3-amino-4-fluorophenoxy)pyridin-2-yl)methyl S-methyl carbonodithioate

There total 10 articles about O-(5-(3-amino-4-fluorophenoxy)pyridin-2-yl)methyl S-methyl carbonodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxy-2-fluoroaniline (62257-16-3) → O-(5-(3-amino-4-fluorophenoxy)pyridin-2-yl)methyl S-methyl carbonodithioate (1025456-64-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h

1.2: 80 °C

2.1: sodium hydroxide; water / ethanol / 85 °C

2.2: pH 1-2

3.1: diborane / tetrahydrofuran / 7.5 h / 0 - 20 °C

3.2: 1 h / 50 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 1 h / 0 °C

4.3: 0 - 20 °C

With potassium tert-butylate; water; sodium hydride; sodium hydroxide; diborane; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide;

Reference yield:

5-(3-amino-4-fluorophenoxy)picolinic acid (1020172-94-4) + methyl iodide (74-88-4) → O-(5-(3-amino-4-fluorophenoxy)pyridin-2-yl)methyl S-methyl carbonodithioate (1025456-64-7)

Guidance literature:

5-(3-amino-4-fluorophenoxy)picolinic acid; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

With carbon disulfide; In tetrahydrofuran; at 0 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + (5-(3-amino-4-fluorophenoxy)pyridin-2-yl)methanol (1020172-95-5) + methyl iodide (74-88-4) → O-(5-(3-amino-4-fluorophenoxy)pyridin-2-yl)methyl S-methyl carbonodithioate (1025456-64-7)

Guidance literature:

(5-(3-amino-4-fluorophenoxy)pyridin-2-yl)methanol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

carbon disulfide; In tetrahydrofuran; at 0 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃;

upstream raw materials:

5-(3-amino-4-fluorophenoxy)picolinic acid

methyl iodide

5-hydroxy-2-fluoroaniline

5-(3-amino-4-fluorophenoxy)picolinonitrile

Downstream raw materials:

2-fluoro-5-(6-methylpyridin-3-yloxy)benzenamine

Refernces

• 1、 -. "KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES". Page/Page column 36. . Retrieved 2008/06/13.