3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone

Base Information

Chemical Name:3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone
CAS No.:736945-96-3
Molecular Formula:C₂₀H₁₉N₃O₂S
Molecular Weight:365.456
Hs Code.:
UNII:WV82DEG4YA
DSSTox Substance ID:DTXSID701336625
Wikipedia:GSK417651A
Wikidata:Q101811082
Pharos Ligand ID:JQXMDJCG7JKY
ChEMBL ID:CHEMBL1506485

Synonyms:GSK417651A;736945-96-3;WV82DEG4YA;GSK-417651A;UNII-WV82DEG4YA;MLS000718305;TRPC3/6-IN-1;3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone;SMR000290573;(3,4-Dihydro-2(1H)-isoquinolinyl)(2-((4-methoxyphenyl)amino)-4-thiazolyl)methanone;(3,4-dihydroisoquinolin-2(1H)-yl)(2-((4-methoxyphenyl)amino)thiazol-4-yl)methanone;Isoquinoline, 1,2,3,4-tetrahydro-2-((2-((4-methoxyphenyl)amino)-4-thiazolyl)carbonyl)-;Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)(2-((4-methoxyphenyl)amino)-4-thiazolyl)-;SCHEMBL789016;CHEMBL1506485;BDBM43434;cid_1096735;GTPL10279;DTXSID701336625;HMS2685G12;STK102314;AKOS000617430;compound 3 [PMID: 23886683];HY-147357;CS-0567244;Z1250803939;3,4-dihydro-1H-isoquinolin-2-yl-[2-(p-anisidino)thiazol-4-yl]methanone;3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-4-thiazolyl]methanone;3,4-dihydro-1H-isoquinolin-2-yl-[2-[(4-methoxyphenyl)amino]-1,3-thiazol-4-yl]methanone;3,4-dihydroisoquinolin-2(1H)-yl{2-[(4-methoxyphenyl)amino]-1,3-thiazol-4-yl}methanone;N-(4-methoxyphenyl)-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1,3-thiazol-2-amine

Suppliers and Price of 3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:365.11979803
Heavy Atom Count:26
Complexity:484

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)NC2=NC(=CS2)C(=O)N3CCC4=CC=CC=C4C3

Technology Process of 3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone

There total 4 articles about 3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 165682-75-7
2-{[4-(methyloxy)phenyl]amino}-1,3-thiazole-4-carboxylic acid

: 736945-96-3
4-(3,4-dihydro-2(1H)-isoquinolinylcarbonyl)-N-[4-(methyloxy)phenyl]-1,3-thiazol-2-amine

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 23 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2013.06.047

Reference yield:

: 104-94-9
4-methoxy-aniline

: 736945-96-3
4-(3,4-dihydro-2(1H)-isoquinolinylcarbonyl)-N-[4-(methyloxy)phenyl]-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 4 h / 150 °C / Microwave irradiation

2: methanol; lithium hydroxide / tetrahydrofuran / 18 h / 23 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 23 °C

With methanol; ethanol; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.06.047

Reference yield:

: ethyl 2-((4-methoxyphenyl)amino)thiazole-4-carboxylate

: 736945-96-3
4-(3,4-dihydro-2(1H)-isoquinolinylcarbonyl)-N-[4-(methyloxy)phenyl]-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; lithium hydroxide / tetrahydrofuran / 18 h / 23 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 23 °C

With methanol; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.06.047