(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3,3-dimethylbutanoic acid

Base Information

Chemical Name:(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3,3-dimethylbutanoic acid
CAS No.:1469996-64-2
Molecular Formula:C₂₀H₂₂ClNO₄
Molecular Weight:375.852
Hs Code.:

Synonyms:(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3,3-dimethylbutanoic acid

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Chemical Property of (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3,3-dimethylbutanoic acid

Chemical Property:

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Technology Process of (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3,3-dimethylbutanoic acid

There total 3 articles about (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3,3-dimethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1469996-57-3
methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3,3-dimethyl]butanoate

: 1469996-64-2
(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3,3-dimethylbutanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In 1,4-dioxane; water; at 50 ℃; for 0.75h;
DOI:10.1016/j.ejmech.2013.08.009

Reference yield:

: 63038-27-7,167223-43-0
L-tert-leucine methyl ester hydrochloride

: 1469996-64-2
(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3,3-dimethylbutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16.5 h / 5 - 20 °C

2: lithium hydroxide monohydrate / 1,4-dioxane; water / 0.75 h / 50 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.08.009

Reference yield:

: 139163-43-2
(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride

: 1469996-64-2
(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3,3-dimethylbutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 16 h / -10 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16.5 h / 5 - 20 °C

3: lithium hydroxide monohydrate / 1,4-dioxane; water / 0.75 h / 50 °C

With thionyl chloride; lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.08.009