(R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

Base Information

Chemical Name:(R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile
CAS No.:158705-89-6
Molecular Formula:C₁₀H₁₁NO₃
Molecular Weight:193.202
Hs Code.:

Synonyms:(R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

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Technology Process of (R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

There total 5 articles about (R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 74-90-8
hydrogen cyanide

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 158705-89-6
(R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

Guidance literature:: With Prunus communis hydroxynitrile lyase 5 L₃₃₁V mutant; In tert-butyl methyl ether; at 10 ℃; for 12h; pH=3.5; Reagent/catalyst; enantioselective reaction; Catalytic behavior; Enzymatic reaction;
DOI:10.1021/acscatal.0c01103

Reference yield:

: 74-90-8
hydrogen cyanide

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 158705-89-6
(R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

: 2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

Guidance literature:: With tartrate buffer; In di-isopropyl ether; at 5 ℃; for 68h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; apple meal (R)-oxynitrilase;
DOI:10.1016/S0957-4166(97)00080-3

Reference yield:

: 151-50-8
potassium cyanide

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 158705-89-6
(R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

: 2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

Guidance literature:: With Prunus mume (R)-hydroxynitrile lyase; citrate buffer; In di-isopropyl ether; for 48h; pH=4.0; Title compound not separated from byproducts;
DOI:10.1016/j.tet.2005.08.105