(R)-tert-butyl-3-(3-chlorophenyl)propyl(1-(naphthalen-1-yl)-ethyl)carbamate

Base Information

Chemical Name:(R)-tert-butyl-3-(3-chlorophenyl)propyl(1-(naphthalen-1-yl)-ethyl)carbamate
CAS No.:1355993-08-6
Molecular Formula:C₂₆H₃₀ClNO₂
Molecular Weight:423.983
Hs Code.:

Synonyms:(R)-tert-butyl-3-(3-chlorophenyl)propyl(1-(naphthalen-1-yl)-ethyl)carbamate

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Chemical Property of (R)-tert-butyl-3-(3-chlorophenyl)propyl(1-(naphthalen-1-yl)-ethyl)carbamate

Chemical Property:

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Technology Process of (R)-tert-butyl-3-(3-chlorophenyl)propyl(1-(naphthalen-1-yl)-ethyl)carbamate

There total 4 articles about (R)-tert-butyl-3-(3-chlorophenyl)propyl(1-(naphthalen-1-yl)-ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 518335-32-5
tert-butyl (R)-1-(naphthalen-1-yl)ethylcarbamate

: 61220-44-8
3-(3-chlorophenyl)propyl 4-methylbenzenesulfonate

: 1355993-08-6
(R)-tert-butyl-3-(3-chlorophenyl)propyl(1-(naphthalen-1-yl)-ethyl)carbamate

Guidance literature:: tert-butyl (R)-1-(naphthalen-1-yl)ethylcarbamate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

3-(3-chlorophenyl)propyl 4-methylbenzenesulfonate; In N,N-dimethyl-formamide; at 35 ℃; for 24h;
DOI:10.1021/jo202566h

Reference yield:

: 1866-38-2,14473-90-6
3-chlorocinnamic acid

: 1355993-08-6
(R)-tert-butyl-3-(3-chlorophenyl)propyl(1-(naphthalen-1-yl)-ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: platinum(IV) oxide; hydrogen / ethyl acetate / 48 h / 20 °C / 760.05 Torr

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux

2.2: 0 °C

3.1: dmap; triethylamine / dichloromethane / 40 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 24 h / 35 °C

With dmap; platinum(IV) oxide; lithium aluminium tetrahydride; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo202566h

Reference yield:

: 22991-03-3
3-(3-chlorophenyl)propanol

: 1355993-08-6
(R)-tert-butyl-3-(3-chlorophenyl)propyl(1-(naphthalen-1-yl)-ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 40 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 24 h / 35 °C

With dmap; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo202566h