4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester

Base Information

• Chemical Name: 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester
• CAS No.: 20737-48-8
• Molecular Formula: C7H9NO3S
• Molecular Weight: 187.219
• Hs Code.: 2934100090
• Mol file: 20737-48-8.mol

Synonyms:4-Hydroxy-2-methylthiazole-5-carboxylicacid ethyl ester;Ethyl4-hydroxy-2-methylthiazole-5-carboxylate;

Chemical Property of 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester

Chemical Property:

• Vapor Pressure: 0.00405mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 270.7 °C at 760 mmHg
• PKA: 8.56±0.20(Predicted)
• Flash Point: 117.5 °C
• PSA: 87.66000
• Density: 1.325 g/cm³
• LogP: 1.33380
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-Hydroxy-2-methylthiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester

There total 4 articles about 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

diethyl 2-chloromalonate (14064-10-9) + thioacetamide (62-55-5) → ethyl-4-hydroxy-2-methylthiazole-5-carboxylate (20737-48-8)

Guidance literature:

With 1-(n-butyl)-3-methylimidazolium triflate; at 20 ℃;

DOI:10.1007/s00706-008-0065-7

Reference yield: 78.0%

thioacetamide (62-55-5) + Diethyl 2-bromomalonate (685-87-0) → ethyl-4-hydroxy-2-methylthiazole-5-carboxylate (20737-48-8)

Guidance literature:

With pyridine; In ethanol; at 78 ℃; for 2h;

DOI:10.1021/acs.jafc.8b06935

Reference yield: 29.0%

ethyl 2-bromopropanedioic acid diethyl ester (29237-78-3) + thioacetamide (62-55-5) → ethyl-4-hydroxy-2-methylthiazole-5-carboxylate (20737-48-8)

Guidance literature:

In toluene; for 4h; Reflux;

upstream raw materials:

thioacetamide

Diethyl 2-bromomalonate

diethyl 2-chloromalonate

ethyl 2-bromopropanedioic acid diethyl ester

Downstream raw materials:

sodium ethanolate

2-methyl-4-oxo-4,5-dihydro-thiazole-5-carboxylic acid ethyl ester; sodium enolate

2-methyl-4-(toluene-4-sulfonyloxy)-thiazole-5-carboxylic acid ethyl ester

4-(3-chlorobenzyloxy)-2-methylthiazole-5-carboxylic acid ethyl ester