3-Amino-1H-indole-2-carboxylic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide

Base Information

• Chemical Name: 3-Amino-1H-indole-2-carboxylic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide
• CAS No.: 143604-03-9
• Molecular Formula: C₁₆H₁₄N₄O₂
• Molecular Weight: 294.313

Synonyms:3-Amino-1H-indole-2-carboxylic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide

Chemical Property of 3-Amino-1H-indole-2-carboxylic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide

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Technology Process of 3-Amino-1H-indole-2-carboxylic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide

There total 2 articles about 3-Amino-1H-indole-2-carboxylic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + 3-Aminoindole-2-carbohydrazide (110963-29-6) → 3-Amino-1H-indole-2-carboxylic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (143604-03-9)

Guidance literature:

In ethanol; for 0.166667h; Heating;

DOI:10.1002/ardp.19923250712

Reference yield:

ethyl 3-amino-1H-indole-2-carboxylate (87223-77-6) → 3-Amino-1H-indole-2-carboxylic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (143604-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / hydrazine hydrate / 4 h / Heating

2: 78 percent / ethanol / 0.17 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1002/ardp.19923250712

Reference yield: 76.0%

3-Amino-1H-indole-2-carboxylic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (143604-03-9) → 3-{[1-(4-Hydroxy-phenyl)-meth-(E)-ylidene]-amino}-3,5-dihydro-[1,2,3]triazino[5,4-b]indol-4-one (139953-76-7)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; for 5h; Ambient temperature;

DOI:10.1002/ardp.19923250712

upstream raw materials:

4-hydroxy-benzaldehyde

3-Aminoindole-2-carbohydrazide

ethyl 3-amino-1H-indole-2-carboxylate

Downstream raw materials:

3-{[1-(4-Hydroxy-phenyl)-meth-(E)-ylidene]-amino}-3,5-dihydro-[1,2,3]triazino[5,4-b]indol-4-one

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