1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea

Base Information

• Chemical Name: 1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea
• CAS No.: 1245612-66-1
• Molecular Formula: C₁₅H₁₈F₃N₃OS
• Molecular Weight: 345.389

Synonyms:1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea

Chemical Property of 1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea

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Technology Process of 1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea

There total 1 articles about 1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-amino-1-(4-methylpiperidin-1-yl)ethanone hydrochloride salt (1219972-14-1) + 1,3,5-trifluoro-2-isothiocyanatobenzene (206761-91-3) → 1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea (1245612-66-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.10.052

Reference yield: 96.0%

1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea (1245612-66-1) + methyl iodide (74-88-4) → 2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea (1245612-67-2)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.10.052

Reference yield:

1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea (1245612-66-1) + methyl iodide (74-88-4) → 2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea (1245612-67-2)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 1h;

upstream raw materials:

2-amino-1-(4-methylpiperidin-1-yl)ethanone hydrochloride salt

1,3,5-trifluoro-2-isothiocyanatobenzene

Downstream raw materials:

2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea

2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea

1-[5-bromo-2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]-4-methylpiperidine

4-methyl-1-[5-methyl-2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]piperidine

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