N-(1-acetyl-1H-indol-2-yl)-N-(4-bromobenzyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(1-acetyl-1H-indol-2-yl)-N-(4-bromobenzyl)-4-methylbenzenesulfonamide
CAS No.:1527501-90-1
Molecular Formula:C₂₄H₂₁BrN₂O₃S
Molecular Weight:497.412
Hs Code.:

Synonyms:N-(1-acetyl-1H-indol-2-yl)-N-(4-bromobenzyl)-4-methylbenzenesulfonamide

Suppliers and Price of N-(1-acetyl-1H-indol-2-yl)-N-(4-bromobenzyl)-4-methylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(1-acetyl-1H-indol-2-yl)-N-(4-bromobenzyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of N-(1-acetyl-1H-indol-2-yl)-N-(4-bromobenzyl)-4-methylbenzenesulfonamide

There total 7 articles about N-(1-acetyl-1H-indol-2-yl)-N-(4-bromobenzyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 10504-96-8
N-[(4-bromophenyl)methyl]-4-methylbenzenesulfonamide

: 693794-61-5
N-[2-(2,2-dibromovinyl)-phenyl]-acetamide

: 1527501-90-1
N-(1-acetyl-1H-indol-2-yl)-N-(4-bromobenzyl)-4-methylbenzenesulfonamide

Guidance literature:: With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/ol403365

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 1527501-90-1
N-(1-acetyl-1H-indol-2-yl)-N-(4-bromobenzyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C

2: tin(II) chloride dihdyrate / ethanol / 0.75 h / 100 °C / Inert atmosphere

3: pyridine / dichloromethane / 3 h / 20 °C

4: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / tetrahydrofuran / 24 h / 20 °C

With pyridine; copper(l) iodide; 1,10-Phenanthroline; tin(II) chloride dihdyrate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol403365

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1527501-90-1
N-(1-acetyl-1H-indol-2-yl)-N-(4-bromobenzyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

2: acetic acid; hydrogen bromide / 0.5 h / 0 °C

3: ammonia / ethanol; water / 4 h / 20 °C

4: triethylamine / acetonitrile / 4 h / 20 °C

5: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / tetrahydrofuran / 24 h / 20 °C

With sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline; ammonia; hydrogen bromide; caesium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;
DOI:10.1021/ol403365