(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoic acid

Base Information

Chemical Name:(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoic acid
CAS No.:303142-45-2
Molecular Formula:C₃₇H₃₃NO₃
Molecular Weight:539.674
Hs Code.:

Synonyms:(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoic acid

There total 14 articles about (2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 303142-44-1
methyl(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoate

: 303142-45-2
(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoic acid

Guidance literature:: With hydrogenchloride; lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 0.333333h;
DOI:10.1021/jo051403q

Reference yield:

: 77758-51-1
methyl hex-5-ynoate

: 303142-45-2
(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / n-butylamine; CuI / PdCl₂(PPh₃)2 / diethyl ether / 4 h / 0 - 20 °C

2: 94 percent / triethylamine; CuI / Pd(PPh₃)2 / 4 h

3: 89 percent / LiOH*H₂O / H₂O / 6 h / 0 - 20 °C

4: 97 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 12 h / 0 - 20 °C

5: 79 percent / LiOH*HCl / tetrahydrofuran; H₂O / 0.33 h / 0 °C

With hydrogenchloride; lithium hydroxide; copper(l) iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-butylamine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; bis(triphenylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/jo051403q

Reference yield:

: 303142-41-8
methyl 6-(3-iodophenyl)-5-hexynoate

: 303142-45-2
(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / triethylamine; CuI / Pd(PPh₃)2 / 4 h

2: 89 percent / LiOH*H₂O / H₂O / 6 h / 0 - 20 °C

3: 97 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 12 h / 0 - 20 °C

4: 79 percent / LiOH*HCl / tetrahydrofuran; H₂O / 0.33 h / 0 °C

With hydrogenchloride; lithium hydroxide; copper(l) iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis(triphenylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo051403q