methyl(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoate

Base Information

Chemical Name:methyl(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoate
CAS No.:303142-44-1
Molecular Formula:C₃₈H₃₅NO₃
Molecular Weight:553.701
Hs Code.:

Synonyms:methyl(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoate

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Chemical Property of methyl(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoate

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Technology Process of methyl(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoate

There total 11 articles about methyl(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 303142-43-0
6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoic acid

: 303142-44-1
methyl(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;
DOI:10.1021/jo051403q

Reference yield:

: 77758-51-1
methyl hex-5-ynoate

: 303142-44-1
methyl(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / n-butylamine; CuI / PdCl₂(PPh₃)2 / diethyl ether / 4 h / 0 - 20 °C

2: 94 percent / triethylamine; CuI / Pd(PPh₃)2 / 4 h

3: 89 percent / LiOH*H₂O / H₂O / 6 h / 0 - 20 °C

4: 97 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 12 h / 0 - 20 °C

With lithium hydroxide; copper(l) iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-butylamine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; bis(triphenylphosphine)palladium⁽⁰⁾; In diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/jo051403q

Reference yield:

: 303142-41-8
methyl 6-(3-iodophenyl)-5-hexynoate

: 303142-44-1
methyl(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / triethylamine; CuI / Pd(PPh₃)2 / 4 h

2: 89 percent / LiOH*H₂O / H₂O / 6 h / 0 - 20 °C

3: 97 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 12 h / 0 - 20 °C

With lithium hydroxide; copper(l) iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis(triphenylphosphine)palladium⁽⁰⁾; In water; N,N-dimethyl-formamide;
DOI:10.1021/jo051403q