Technology Process of 5-isopropyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione
There total 3 articles about 5-isopropyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chloro-trimethyl-silane; sodium iodide;
In
acetonitrile;
at 20 ℃;
for 24h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2012.06.143
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tert-butyl alcohol / 8 h / Reflux
2.1: sodium dithionite / ethanol; water / 6 h / Reflux
3.1: tetrabutylammomium bromide; potassium hydroxide / tetrahydrofuran / 0.5 h / 20 °C
3.2: 2 h / 50 °C
4.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 24 h / 20 °C / Inert atmosphere
With
chloro-trimethyl-silane; sodium dithionite; tetrabutylammomium bromide; sodium iodide; potassium hydroxide;
In
tetrahydrofuran; ethanol; water; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2012.06.143
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium dithionite / ethanol; water / 6 h / Reflux
2.1: tetrabutylammomium bromide; potassium hydroxide / tetrahydrofuran / 0.5 h / 20 °C
2.2: 2 h / 50 °C
3.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 24 h / 20 °C / Inert atmosphere
With
chloro-trimethyl-silane; sodium dithionite; tetrabutylammomium bromide; sodium iodide; potassium hydroxide;
In
tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1016/j.tetlet.2012.06.143
![5-isopropyl-2,4-dimethoxy-9-phenyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one](/Databaselist/images/loading.webp)
